ArticleThe American journal of clinical nutrition2007
Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements for choline.
Article in The American journal of clinical nutrition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- TL-HDMR: a transfer learning framework for advancing equitable causal inference reveals metabolic signatures of stroke across multiple ancestries.Briefings in bioinformatics · 2026Article
- Nutrigenomics: A tool to unlock genetic potential of Nigerian indigenous goat breeds.Open veterinary journal · 2025Review
- Mass-spectrometry based metabolomics: an overview of workflows, strategies, data analysis and applications.Proteome science · 2025Review
- Specific Genotypes Associated with Differences in Fasting Insulin Levels and Body Mass Index in Healthy Young Males: Implications for Gene-Nutrient Interactions-an Exploratory Study.Current developments in nutrition · 2023Article
- Integrating (Nutri-)Metabolomics into the One Health Tendency-The Key for Personalized Medicine Advancement.Metabolites · 2023Review
- Hepatic oleate regulates one-carbon metabolism during high carbohydrate feeding.Biochemical and biophysical research communications · 2023Article
- Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.Public health nutrition · 2021Article
- Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism.NPJ precision oncology · 2017Article
- Sparse meta-analysis with high-dimensional data.Biostatistics (Oxford, England) · 2016Article
- Toward a new philosophy of preventive nutrition: from a reductionist to a holistic paradigm to improve nutritional recommendations.Advances in nutrition (Bethesda, Md.) · 2014Review
- Epigenetic effects of human breast milk.Nutrients · 2014Review
- Highlights of the 2012 Research Workshop: Using nutrigenomics and metabolomics in clinical nutrition research.JPEN. Journal of parenteral and enteral nutrition · 2013Article
- Integrative oncology meets immunotherapy: new prospects for combination therapy grounded in Eastern medical knowledge.Chinese journal of integrative medicine · 2012Review
- Redefining the impact of nutrition on breast cancer incidence: is epigenetics involved?Nutrition research reviews · 2012Review
- The Regulation of Leptin, Leptin Receptor and Pro-opiomelanocortin Expression by N-3 PUFAs in Diet-Induced Obese Mice Is Not Related to the Methylation of Their Promoters.Nutrition & metabolism · 2011Article
- Nutrigenomics and personalized diets: What will they mean for food?Annual review of food science and technology · 2011Review
- Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Integrating the totality of food and nutrition evidence for public health decision making and communication.Critical reviews in food science and nutrition · 2010Article
- Metabolomics for assessment of nutritional status.Current opinion in clinical nutrition and metabolic care · 2009Review
- Intake of B vitamins in childhood and adult life in relation to psychological distress among women in a British birth cohort.Public health nutrition · 2009Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Science is beginning to understand how genetic variation and epigenetic events alter requirements for, and responses to, nutrients (nutrigenomics). At the same time, methods for profiling almost all of the products of metabolism in a single sample of blood or urine are being developed (metabolomics). Relations between diet and nutrigenomic and metabolomic profiles and between those profiles and health have become important components of research that could change clinical practice in nutrition. Most nutrition studies assume that all persons have average dietary requirements, and the studies often do not plan for a large subset of subjects who differ in requirements for a nutrient. Large variances in responses that occur when such a population exists can result in statistical analyses that argue for a null effect. If nutrition studies could better identify responders and differentiate them from nonresponders on the basis of nutrigenomic or metabolomic profiles, the sensitivity to detect differences between groups could be greatly increased, and the resulting dietary recommendations could be appropriately targeted. It is not certain that nutrition will be the clinical specialty primarily responsible for nutrigenomics or metabolomics, because other disciplines currently dominate the development of portions of these fields. However, nutrition scientists' depth of understanding of human metabolism can be used to establish a role in the research and clinical programs that will arise from nutrigenomic and metabolomic profiling. Investments made today in training programs and in research methods could ensure a new foundation for clinical nutrition in the future.
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