ArticleThe American journal of pathology2007
Dissecting the impact of chemotherapy on the human hair follicle: a pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophy.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 116 citations in OpenAlex.
- An extract of Leontopodium alpinum inhibits catagen development ex vivo and increases hair density in vivo.International journal of cosmetic science · 2022Trial
- Scalp Cooling as a Biopsychosocial Intervention in Patients Receiving Highly Alopecia-Inducing Chemotherapy: Prospective Single-Arm Study.JMIR cancer · 2026Article
- Treatment With Ashwagandha-Derived Exosome-Like Nanovesicles Up-Regulates VEGF-A Production and Promotes Human Hair Growth Ex Vivo.Experimental dermatology · 2026Article
- Not just splitting hairs-monitoring environmental chemical exposures, their biological effects and their social determinants with hair shafts and follicles: a narrative review.Environmental health : a global access science source · 2026Review
- Immunopathogenesis and Experimental Models of Alopecia Areata: From Mechanistic Insights to Translational Platforms.Clinical reviews in allergy & immunology · 2026Review
- Chemotherapy-Induced Alopecia Beyond Cytotoxicity: Hair Follicle Immune Privilege Collapse and JAK-STAT Signaling.International journal of molecular sciences · 2026Review
- Transient p53/p21 activation selectively protects healthy human hair follicles and their stem cells from chemotherapy.The Journal of clinical investigation · 2026Article
- Convergence of external and internal stressors on a stress-responsive enhancer of theProceedings of the National Academy of Sciences of the United States of America · 2026Article
- An Exploratory Preclinical In Vivo Pilot Study Evaluating the Hair Growth-Promoting Effects of Rosmarinus officinalis and Ricinus communis Combination.BioMed research international · 2026Article
- Protective Effects of Korean Red Ginseng Against Oxidative Stress-Induced Damage in Human Hair.Annals of dermatology · 2025Article
- Prevention of chemotherapy drug-mediated human hair follicle damage: combined use of cooling with antioxidant suppresses oxidative stress and prevents matrix keratinocyte cytotoxicity.Frontiers in pharmacology · 2025Article
- New Plant Extracts Exert Complementary Anti-Hair Loss Properties in Human In Vitro and Ex Vivo Models.Journal of cosmetic dermatology · 2024Article
- Cytoprotective role of human dental pulp stem cell-conditioned medium in chemotherapy-induced alopecia.Stem cell research & therapy · 2024Article
- A pig model exploring the postnatal hair follicle cycle.Frontiers in cell and developmental biology · 2024Article
- A CD6-targeted antibody-drug conjugate as a potential therapy for T cell-mediated disorders.JCI insight · 2023Article
- Prevention and Treatment of Chemotherapy-Induced Alopecia: What Is Available and What Is Coming?Current oncology (Toronto, Ont.) · 2023Review
- Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata.eLife · 2023Article
- The global regulatory logic of organ regeneration: circuitry lessons from skin and its appendages.Biological reviews of the Cambridge Philosophical Society · 2021Article
- Network Pharmacology Study and Experimental Confirmation Revealing the Ameliorative Effects of Decursin on Chemotherapy-Induced Alopecia.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemotherapy-induced alopecia represents one of the major unresolved problems of clinical oncology. The underlying molecular pathogenesis in humans is virtually unknown because of the lack of adequate research models. Therefore, we have explored whether microdissected, organ-cultured, human scalp hair follicles (HFs) in anagen VI can be exploited for dissecting and manipulating the impact of chemotherapy on human HFs. Here, we show that these organ-cultured HFs respond to a key cyclophosphamide metabolite, 4-hydroperoxycyclophosphamide (4-HC), in a manner that resembles chemotherapy-induced HF dystrophy as it occurs in vivo: namely, 4-HC induced melanin clumping and melanin incontinence, down-regulated keratinocyte proliferation, massively up-regulated apoptosis of hair matrix keratinocytes, prematurely induced catagen, and up-regulated p53. In addition, 4-HC induced DNA oxidation and the mitochondrial DNA common deletion. The organ culture system facilitated the identification of new molecular targets for chemotherapy-induced HF damage by microarray technology (eg, interleukin-8, fibroblast growth factor-18, and glypican 6). It was also used to explore candidate chemotherapy protectants, for which we used the cytoprotective cytokine keratinocyte growth factor as exemplary pilot agent. Thus, this novel system serves as a powerful yet pragmatic tool for dissecting and manipulating the impact of chemotherapy on the human HF.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.