ArticleThe American journal of pathology2007
Targeting inflammatory demyelinating lesions to sites of Wallerian degeneration.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- Impact of histone modifier-induced protection against autoimmune encephalomyelitis on multiple sclerosis treatment.Frontiers in neurology · 2022Review
- Immunoregulation of Theiler's virus-induced demyelinating disease by glatiramer acetate without suppression of antiviral immune responses.Archives of virology · 2018Article
- Gut dysbiosis and neuroimmune responses to brain infection with Theiler's murine encephalomyelitis virus.Scientific reports · 2017Article
- Three immune-mediated disease models induced by Theiler's virus: Multiple sclerosis, seizures and myocarditis.Clinical & experimental neuroimmunology · 2016Article
- NBQX, a highly selective competitive antagonist of AMPA and KA ionotropic glutamate receptors, increases seizures and mortality following picornavirus infection.Experimental neurology · 2016Article
- Interferon-stimulated genes-essential antiviral effectors implicated in resistance to Theiler's virus-induced demyelinating disease.Journal of neuroinflammation · 2015Article
- "Microglial nodules" and "newly forming lesions" may be a Janus face of early MS lesions; implications from virus-induced demyelination, the Inside-Out model.BMC neurology · 2015Review
- Animal models of Multiple Sclerosis.European journal of pharmacology · 2015Review
- The primate autoimmune encephalomyelitis model; a bridge between mouse and man.Annals of clinical and translational neurology · 2015Review
- Thalamus pathology in multiple sclerosis: from biology to clinical application.Cellular and molecular life sciences : CMLS · 2015Review
- Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Axonopathy is associated with complex axonal transport defects in a model of multiple sclerosis.Brain pathology (Zurich, Switzerland) · 2012Article
- Antiviral CD8⁺ T cells cause an experimental autoimmune encephalomyelitis-like disease in naive mice.Journal of neurovirology · 2012Article
- Transgenic expression of viral capsid proteins predisposes to axonal injury in a murine model of multiple sclerosis.Brain pathology (Zurich, Switzerland) · 2011Article
- Theiler's virus infection: Pathophysiology of demyelination and neurodegeneration.Pathophysiology : the official journal of the International Society for Pathophysiology · 2011Article
- Neuropathogenesis of Theiler's murine encephalomyelitis virus infection, an animal model for multiple sclerosis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
- Role for complement in the development of seizures following acute viral infection.Journal of virology · 2010Article
- Mutations in the spike glycoprotein of human coronavirus OC43 modulate disease in BALB/c mice from encephalitis to flaccid paralysis and demyelination.Journal of neurovirology · 2010Article
- Innate but not adaptive immune responses contribute to behavioral seizures following viral infection.Epilepsia · 2010Article
- Inflammation in neurodegenerative diseases.Immunology · 2010Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
In Theiler's murine encephalomyelitis virus (TMEV) infection, an animal model for multiple sclerosis (MS), axonal injury precedes inflammatory demyelinating lesions, and the distribution of axonal damage present during the early phase of infection corresponds to regions where subsequent demyelination occurs during the chronic phase. We hypothesized that axonal damage recruits inflammatory cells to sites of Wallerian degeneration, leading to demyelination. Three weeks after TMEV infection, axonal degeneration was induced in the posterior funiculus of mice by injecting the toxic lectin Ricinus communis agglutinin (RCA) I into the sciatic nerve. Neuropathology was examined 1 week after lectin injection. Control mice, infected with TMEV but receiving no RCA I, had inflammatory demyelinating lesions in the anterior/lateral funiculi. Other control mice that received RCA I alone did not develop inflammatory lesions. In contrast, RCA I injection into TMEV-infected mice induced lesions in the posterior funiculus in addition to the anterior/lateral funiculi. We found no differences in lymphoproliferative responses or antibody titers against TMEV among the groups. This suggests that axonal degeneration contributes to the recruitment of inflammatory cells into the central nervous system by altering the local microenvironment. In this scenario, lesions develop from the axon (inside) to the myelin (outside) (Inside-Out model).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.