Evidence map›Paper›PMID 17822959›Full record

ReviewTrends in molecular medicine2007

Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling.

Gang G Wang, C David Allis, Ping Chi

Abstract readReview
In one paragraph

Review in Trends in molecular medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed.

  1. A comprehensive survey of genetic variants in neuroblastoma.Journal, genetic engineering & biotechnology · 2026
    Article
  2. Review
  3. The role of SMARCA4 in lung cancer.Scientific reports · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Polycomb Repressive Complex 2 in Oncology.Cancer treatment and research · 2023
    Article
  14. Review
  15. Article
  16. Mutations inCancers · 2022
    Article
  17. The Advances in Epigenetics for Cancer Radiotherapy.International journal of molecular sciences · 2022
    Review
  18. Review
  19. Epigenetics in Congenital Heart Disease.Journal of the American Heart Association · 2022
    Review
  20. Article

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gang G WangLaboratory of Chromatin Biology, The Rockefeller University, and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
C David Allis
Ping Chi

Funding

Investigational Cancer Therapeutics Training Program (ICTTP)T32CA009207 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Omar Abdel-Wahab, Alexander Drilon · 1985 to 2026
$13.7M
INFLUENCE OF HISTONE H1 AND HMGS ON GENE EXPRESSIONR01GM040922 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ALLIS, CHARLES DAVID · 1989 to 2022
$10.0M
NCI NIH HHS 5T32CA009207-28NCI NIH HHS T32 CA009207NIGMS NIH HHS R01 GM040922
6 · The paper itself

Abstract

Connections between perturbations that lie outside of our genome, that is, epigenetic alternations, and tumorigenesis have become increasingly apparent. Dynamic chromatin remodeling of the fundamental nucleosomal structure (covered in this review) or the covalent marks residing in the histone proteins that make up this structure (covered previously in part I) underlie many fundamental cellular processes, including transcriptional regulation and DNA-damage repair. Dysregulation of these processes has been linked to cancer development. Mechanisms of chromatin remodeling include dynamic interplay between ATP-dependent complexes, covalent histone modifications, utilization of histone variants and DNA methylation. In part II of this series, we focus on connections between ATP-dependent chromatin-remodeling complexes and oncogenesis and discuss the potential clinical implications of chromatin remodeling and cancer.

Indexed as

Adenosine TriphosphateAnimalsChromatinHistonesHumansModels, BiologicalNeoplasmsProtein Processing, Post-TranslationalAdenosine TriphosphateChromatinHistones

Identifiers

PMID17822959
PMCPMC4337864

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.