ArticleMolecular and cellular neurosciences2007
A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease.
Article in Molecular and cellular neurosciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
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- Nonlipogenic ABCA1 Inducers (NLAI) for Alzheimer's Disease Validated in a Mouse Model Expressing HumanJournal of medicinal chemistry · 2024Article
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- Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework.Molecular psychiatry · 2021Review
- Transitions in metabolic and immune systems from pre-menopause to post-menopause: implications for age-associated neurodegenerative diseases.F1000Research · 2020Review
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- APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain.Alzheimer's research & therapy · 2019Article
- Chronic Cerebral Hypoperfusion Induced Synaptic Proteome Changes in the rat Cerebral Cortex.Molecular neurobiology · 2018Article
- Gene expression profiles among murine strains segregate with distinct differences in the progression of radiation-induced lung disease.Disease models & mechanisms · 2017Article
- Age and Alzheimer's disease gene expression profiles reversed by the glutamate modulator riluzole.Molecular psychiatry · 2017Article
- Triad of Risk for Late Onset Alzheimer's: Mitochondrial Haplotype, APOE Genotype and Chromosomal Sex.Frontiers in aging neuroscience · 2016Review
- Rare Variants and Transcriptomics in Alzheimer disease.Current genetic medicine reports · 2014Article
- ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice.Molecular neurodegeneration · 2013Article
- Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease.Acta neuropathologica communications · 2013Article
- RNA-Seq and human complex diseases: recent accomplishments and future perspectives.European journal of human genetics : EJHG · 2013Review
- KIAA1462, a coronary artery disease associated gene, is a candidate gene for late onset Alzheimer disease in APOE carriers.PloS one · 2013Article
- Genetic variants and monoallelic expression of surfactant protein-D in inflammatory bowel disease.Annals of human genetics · 2011Article
- Article
- A serial analysis of gene expression profile of the Alzheimer's disease Tg2576 mouse model.Neurotoxicity research · 2010Article
- Application of serial analysis of gene expression to the study of human genetic disease.Human genetics · 2009Review
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
Abstract
APOE4 allele is a major risk factor for late-onset Alzheimer disease (AD). The mechanism of action of APOE in AD remains unclear. To study the effects of APOE alleles on gene expression in AD, we have analyzed the gene transcription patterns of human hippocampus from APOE3/3, APOE3/4, APOE4/4 AD patients and normal control using Serial Analysis of Gene Expression (SAGE). Using SAGE, we found gene expression patterns in hippocampus of APOE3/4 and APOE4/4 AD patients differ substantially from those of APOE3/3 AD patients. APOE3/4 and APOE4/4 allele expression may activate similar genes or gene pools with associated functions. APOE4 AD alleles activate multiple tumor suppressors, tumor inducers and negative regulator of cell growth or repressors that may lead to increased cell arrest, senescence and apoptosis. In contrast, there is decreased expression of large clusters of genes associated with synaptic plasticity, synaptic vesicle docking and fusing and axonal/neuronal outgrowth. In addition, reduction of neurotransmitter receptors and Ca2+ homeostasis, disruption of multiple signal transduction pathways, loss of cell protection, and perhaps most notably, mitochondrial oxidative phosphorylation/energy metabolism are associated with APOE3/4 and APOE4/4 AD alleles. These findings may help define the mechanisms that APOE4 contribute that increase risk for AD and identify new candidate genes conferring susceptibility to AD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.