ArticleExperimental neurology2007
Comparison of the effects of complete and incomplete spinal cord injury on lower urinary tract function as evaluated in unanesthetized rats.
Article in Experimental neurology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Assessing Neurogenic Lower Urinary Tract Dysfunction after Spinal Cord Injury: Animal Models in Preclinical Neuro-Urology Research.Biomedicines · 2023Review
- Upregulated 5-HTJournal of neurotrauma · 2023Article
- Thoracolumbar epidural stimulation effects on bladder and bowel function in uninjured and chronic transected anesthetized rats.Scientific reports · 2022Article
- Serial transurethral cystometry: A novel method for longitudinal evaluation of reflex lower urinary tract function in adult female rats.Physiological reports · 2022Article
- Improvement of lower urinary tract function by a selective serotonin 5-HTExperimental neurology · 2020Article
- Spinal Transection Alters External Urethral Sphincter Activity during Spontaneous Voiding in Freely Moving Rats.Journal of neurotrauma · 2017Article
- Tanshinone IIA improves functional recovery in spinal cord injury-induced lower urinary tract dysfunction.Neural regeneration research · 2017Article
- Transplantation of neural progenitor cells in chronic spinal cord injury.Neuroscience · 2016Article
- Article
- Long-term recording of external urethral sphincter EMG activity in unanesthetized, unrestrained rats.American journal of physiology. Renal physiology · 2014Article
- Omega-conotoxin MVIIC attenuates neuronal apoptosis in vitro and improves significant recovery after spinal cord injury in vivo in rats.International journal of clinical and experimental pathology · 2014Article
- Enhanced susceptibility to urinary tract infection in the spinal cord-injured host with neurogenic bladder.Infection and immunity · 2013Article
- Nerve regeneration restores supraspinal control of bladder function after complete spinal cord injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The impact of discrete modes of spinal cord injury on bladder muscle contractility.BMC urology · 2013Article
- Neural control of the female urethral and anal rhabdosphincters and pelvic floor muscles.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Review
- A bilateral cervical contusion injury model in mice: assessment of gripping strength as a measure of forelimb motor function.Experimental neurology · 2010Article
- FTY720 reduces inflammation and promotes functional recovery after spinal cord injury.Journal of neurotrauma · 2009Article
- Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In rats, phasic external urethral sphincter (EUS) activity (bursting) is postulated to be crucial for efficient voiding. This has been reported to be lost after spinal cord transection (txSCI), contributing to impaired function. However, anesthesia may confound evaluating EUS activity. We therefore evaluated urodynamic parameters in unanesthetized, restrained rats and compared the effects of txSCI to that of a clinically relevant, incomplete, contusive injury (iSCI) on lower urinary tract function. Adult female rats were subjected to txSCI or standardized iSCI at the T8 vertebral level. As expected, all injured rats were initially unable to void but developed a reflex bladder with time, with iSCI rats recovering more rapidly than txSCI rats. LUT function was evaluated urodynamically at 2 and 6 weeks after injury. In response to infusion of saline into the bladder, controls consistently exhibited coordinated contraction of the bladder and activation of the EUS in a phasic pattern and had a high voiding efficiency (86.4+/-2.5%). Voiding efficiency of iSCI rats was reduced to approximately 57% and txSCI rats to approximately 32%. However, two different patterns of EUS activity during voiding were present in both txSCI and iSCI groups at both time points: (1) rats with phasic EUS activity, similar to controls and (2) those that only exhibited tonic EUS activity during voiding. The former had more normal voiding efficiencies. Thus, phasic EUS activity and the improved voiding efficiency associated with it can occur and can be detected in unanesthetized rats after both incomplete and complete SCI.
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Registered trials
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