ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2007
Action mechanism of bis(allixinato)oxovanadium(IV) as a novel potent insulin-mimetic complex: regulation of GLUT4 translocation and FoxO1 transcription factor.
Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 67 citations in OpenAlex.
- Coordination chemistry may explain pharmacokinetics and clinical response of vanadyl sulfate in type 2 diabetic patients.Metallomics : integrated biometal science · 2013Trial
- Enhanced Therapeutic Efficacy of Lispro-Protamine Insulin Via Vanadate and Decavanadate Functionalization in a Type 1 Diabetes Murine Model.Biological trace element research · 2026Article
- Antidiabetic potential of vanadium complexes combined with olive leaf extracts: a viable approach to reduce metal toxicity.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Binding Zinc and Oxo-Vanadium Insulin-Mimetic Complexes to Phosphatase Enzymes: Structure, Electronics and Implications.Molecules (Basel, Switzerland) · 2025Article
- Synthesis and crystal structure of bis-(2-aminobenzimidazolium)Acta crystallographica. Section E, Crystallographic communications · 2024Article
- Crystal structures of a series of bis-(acetyl-aceto-nato)oxovanadium(IV) complexes containing N-donor pyridyl ligands.Acta crystallographica. Section E, Crystallographic communications · 2020Article
- Vanadium in Biological Action: Chemical, Pharmacological Aspects, and Metabolic Implications in Diabetes Mellitus.Biological trace element research · 2019Review
- Vanadate inhibits transcription of the rat insulin receptor gene via a proximal sequence of the 5'flanking region.Biochimie open · 2018Article
- Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications.Coordination chemistry reviews · 2018Review
- Bis(hinokitiolato)zinc complex ([Zn(hkt)2]) activates Akt/protein kinase B independent of insulin signal transduction.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2016Article
- Vanadium compounds in medicine.Coordination chemistry reviews · 2015Review
- The Structural Basis of Action of Vanadyl (VOCoordination chemistry reviews · 2014Article
- Anti-diabetic effects of a series of vanadium dipicolinate complexes in rats with streptozotocin-induced diabetes.Coordination chemistry reviews · 2011Article
- Antidiabetic vanadium compound and membrane interfaces: interface-facilitated metal complex hydrolysis.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2011Article
- (Acetyl-acetonato-κO,O')(2-bromo-4-chloro-6-{[2-(dimethyl-amino)-ethyl-imino]-meth-yl}phenolato-κN,N',O)oxidovanadium(IV).Acta crystallographica. Section E, Structure reports online · 2011Article
- Altered fibroblast proliferation and apoptosis in diabetic gingival wounds.Journal of dental research · 2010Article
- Molecular mechanism of antidiabetic zinc-allixin complexes: regulations of glucose utilization and lipid metabolism.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2008Article
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5 authors at 2 institutions in 1 country.
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Abstract
Bis(allixinato)oxovanadium(IV), VO(alx)(2) (alx is 3-hydroxy-5-methoxy-6-methyl-2-pentyl-4-pyrone), has been reported to act as an antidiabetic agent in streptozotocin-induced type-1-like and obesity-linked KKA(y) type 2 diabetic model mice. VO(alx)(2) is also proposed as a candidate agent for treating metabolic syndromes in animals. However, its functional mechanism is yet to be clarified. In this study, we examined whether VO(alx)(2) contributes to both the activation of the insulin signaling cascade that activates glucose transporter 4 (GLUT4) translocation and the regulation of the forkhead box O1 (FoxO1) transcription factor that controls the gene transcription of gluconeogenesis genes. The following three important results were obtained: (1) intracellular vanadium concentration in 3T3-L1 adipocytes is higher after treatment with VO(alx)(2) than with VOSO(4); (2) VO(alx)(2) stimulates the translocation of GLUT4 to the plasma membrane following activation of the tyrosine phosphorylation of the insulin receptor beta-subunit (IRbeta) and insulin receptor substrate (IRS) as well as Akt kinase in 3T3-L1 adipocytes; and (3) the mechanism of inhibition of glucose-6-phosphatase (G6Pase) catalytic subunit gene expression by vanadium is due to disruption of FoxO1 binding with the G6Pase promoter, which indicates that FoxO1 is phosphorylated by VO(alx)(2)-stimulated Akt in HepG2 cells. On the basis of these results, we propose that the critical functions of VO(alx)(2) involve the activation of phosphatidylinositol 3-kinase-Akt signaling through the enhancement of tyrosine phosphorylation of IRbeta and IRS, which in turn transmits the signal to activate GLUT4 translocation, and the regulation of the DNA binding activity of the FoxO1 transcription factor.
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