ReviewSeminars in immunopathology2007
Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC.
Review in Seminars in immunopathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04315376 (Exercise Program and Diet Intervention Attenuated Inflammation Through Down-regulation of ASC Gene and Inflammatory Markers in Obese Adults), which is not on this map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exercise Program and Diet Intervention Attenuated Inflammation Through Down-regulation of ASC Gene and Inflammatory Markers in Obese Adults
Who cites it
46 citing papers in PubMed, 79 citations in OpenAlex.
- Trial
- Effects of Exercise on ASC Methylation and IL-1 Cytokines in Heart Failure.Medicine and science in sports and exercise · 2018Trial
- The inhibition of the Aβ-ASC interaction site suppresses β-amyloid aggregation and cytotoxicity.Frontiers in immunology · 2026Article
- Cognitive Dysfunction and Exercise: From Epigenetic to Genetic Molecular Mechanisms.Molecular neurobiology · 2024Review
- Investigation and Confirmation of PYCARD as a Potential Biomarker for the Management of Psoriasis Disease.Journal of inflammation research · 2024Article
- NLRP3 Inflammasome Involvement in Heart, Liver, and Lung Diseases-A Lesson from Cytokine Storm Syndrome.International journal of molecular sciences · 2023Review
- miR-369-3p Modulates Intestinal Inflammatory Response via BRCC3/NLRP3 Inflammasome Axis.Cells · 2023Article
- Therapeutic Potential of Targeting the NLRP3 Inflammasome in Rheumatoid Arthritis.Inflammation · 2023Review
- NLRP3 Inflammasome in Diabetic Cardiomyopathy and Exercise Intervention.International journal of molecular sciences · 2021Review
- Physical Activity and DNA Methylation in Humans.International journal of molecular sciences · 2021Review
- Apoptosis-associated speck-like protein containing a CARD regulates the growth of pancreatic ductal adenocarcinoma.Scientific reports · 2021Article
- In Situ Delivery and Production System (Journal of personalized medicine · 2021Review
- Low-grade chronic inflammation is attenuated by exercise training in obese adults through down-regulation of ASC gene in peripheral blood: a pilot study.Genes & nutrition · 2020Article
- Oroxindin inhibits macrophage NLRP3 inflammasome activation in DSS-induced ulcerative colitis in mice via suppressing TXNIP-dependent NF-κB pathway.Acta pharmacologica Sinica · 2020Article
- The Challenge by Multiple Environmental and Biological Factors Induce Inflammation in Aging: Their Role in the Promotion of Chronic Disease.Frontiers in immunology · 2020Review
- Anti-inflammatory Effect of Total Saponin Fraction from Dioscorea nipponica Makino on Gouty Arthritis and Its Influence on NALP3 Inflammasome.Chinese journal of integrative medicine · 2019Article
- Physical activity in the prevention of human diseases: role of epigenetic modifications.BMC genomics · 2017Review
- Inflammasomes and IL-1 biology in the pathogenesis of allograft dysfunction.The Journal of clinical investigation · 2017Review
- FOXO1, PXK, PYCARD and SAMD9L are differentially expressed by fibroblast-like cells in equine synovial membrane compared to joint capsule.BMC veterinary research · 2017Article
- Manual Acupuncture Suppresses the Expression of Proinflammatory Proteins Associated with the NLRP3 Inflammasome in the Hippocampus of SAMP8 Mice.Evidence-based complementary and alternative medicine : eCAM · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recent identification of cytosolic pattern recognition receptors (PRRs) with leucine-rich repeats, which recognize pathogen-associated molecular patterns (PAMPs), has been garnering considerable attention. Activated PRRs form molecular complexes called inflammasomes, consisting of related proteins that include procaspase 1[interleukin (IL) 1beta converting enzyme (ICE)]. Inflammasomes have been shown to facilitate molecular proximity, stimulate activation of procaspase 1, which consequently produces inflammatory cytokines IL-1beta and IL-18 and ultimately lead to the initiation of innate immunity. An adaptor protein, apoptosis-associated speck-like protein containing a CARD (ASC), which recruits PRRs carrying the pyrin homologous domain (PYD) and procaspase 1 through PYD and CARD, respectively, is responsible for the formation of some inflammasomes and also activation of procaspase 1. In this review, our main attention will be directed to PYD region analysis of ASC to understand the interaction between PYD-carrying PRRs and ASC. Taking into consideration the other aspects of the ASC gene in the proapoptotic ability and down-regulation by methylation, the biological function of ASC will be discussed in relation to the epigenetic aspects of infection, inflammation, and cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.