Trial reportJournal of perinatology : official journal of the California Perinatal Association2007
Apneic preterms and methylxanthines: arousal deficits, sleep fragmentation and suppressed spontaneous movements.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Kinesthetic stimulation versus theophylline for apnea in preterm infants.The Cochrane database of systematic reviews · 2000Pooled it
- Effects of caffeine therapy for apnea of prematurity on sleep and neurodevelopment of preterm infants at 6 months of corrected age.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Trial
- Neuromodulation of Limb Proprioceptive Afferents Decreases Apnea of Prematurity and Accompanying Intermittent Hypoxia and Bradycardia.PloS one · 2016Trial
- Long-term effects of caffeine therapy for apnea of prematurity on sleep at school age.American journal of respiratory and critical care medicine · 2014Trial
- Sleep Signal Analysis for Early Detection of Alzheimer's Disease and Related Dementia (ADRD).IEEE journal of biomedical and health informatics · 2023Article
- Sleep movements and respiratory coupling as a biobehavioral metric for early Alzheimer's disease in independently dwelling adults.BMC geriatrics · 2023Article
- Caffeine is a respiratory stimulant without effect on sleep in the short-term in late-preterm infants.Pediatric research · 2022Article
- Precision caffeine therapy for apnea of prematurity and circadian rhythms: New possibilities open up.Frontiers in pharmacology · 2022Review
- Optimizing respiratory management in preterm infants: a review of adjuvant pharmacotherapies.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Neuromodulatory Support for Breathing and Cardiovascular Action During Development.Frontiers in pediatrics · 2021Review
- Caffeine preserves quiet sleep in preterm neonates.Pharmacology research & perspectives · 2020Observational
- Quiet Sleep Organization of Very Preterm Infants Is Correlated With Postnatal Maturation.Frontiers in pediatrics · 2020Article
- Caffeine therapy in preterm infants.World journal of clinical pediatrics · 2015Review
- Caffeine in the neonatal period induces long-lasting changes in sleep and breathing in adult rats.The Journal of physiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine if apneic preterm infants currently treated with methylxanthines develop evidence of sleep deprivation from cumulative arousal and motor activational effects. STUDY
designSleep, wake, arousal and actigraphic movements were monitored in extubated clinically stable premature infants (N=37). Neonates were free of other medications for >72 h and were grouped based on methylxanthine exposure: >5 days with caffeine (n=14), >5 days theophylline (n=13) or no prior exposure (n=10).
resultDuration of methylxanthine treatment predicted increased arousals, wakefulness and actigraphic movements, and decreased active sleep. Recording from 1200 to 0500 hours, methylxanthine-treated groups showed reductions in all arousal parameters: waking state, number of wake epochs, brief arousals and composite arousal index, and shorter fast-burst, sleep-related motility than untreated controls.
conclusionIn apneic preterms, chronic methylxanthine treatment appears to produce sleep deprivation secondary to the stimulatory action of methylxanthines on arousal and motor systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.