ArticlePediatric research2007
Butyrate regulates the expression of pathogen-triggered IL-8 in intestinal epithelia.
Article in Pediatric research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Probiotics-supplemented feeding in extremely low-birth-weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2012Trial
- Bush medicine of the Mbabaram Aboriginal community in Far North Queensland demonstrates strong antioxidant and anti-inflammatory activities.BMC complementary medicine and therapies · 2025Article
- Effect of Butyrate on Food-Grade Titanium Dioxide Toxicity in Different Intestinal In Vitro Models.Chemical research in toxicology · 2024Article
- Pre- to Postbiotics: The Beneficial Roles of Pediatric Dysbiosis Associated with Inflammatory Bowel Diseases.Microorganisms · 2024Review
- Synergistic Inhibitory Effect of Lactobacillus Cell Lysates and Butyrate on Poly I:C-Induced IL-8 Production in Human Intestinal Epithelial Cells.Probiotics and antimicrobial proteins · 2024Article
- Unraveling the microbiome-metabolome nexus: a comprehensive study protocol for personalized management of Behçet's disease using explainable artificial intelligence.Frontiers in microbiology · 2024Article
- Short-Chain Fatty Acid Levels after Fecal Microbiota Transplantation in a Pediatric Cohort with RecurrentMetabolites · 2023Article
- A Model of iPSC-Derived Macrophages withInternational journal of molecular sciences · 2023Article
- Short-chain fatty acids ameliorate necrotizing enterocolitis-like intestinal injury through enhancing Notch1-mediated single immunoglobulin interleukin-1-related receptor, toll-interacting protein, and A20 induction.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Differential gene expression in iPSC-derived human intestinal epithelial cell layers following exposure to two concentrations of butyrate, propionate and acetate.Scientific reports · 2022Article
- Manipulation of Gut Microbiota as a Key Target for Crohn's Disease.Frontiers in medicine · 2022Review
- Concentrates of two subsets of extracellular vesicles from cow's milk modulate symptoms and inflammation in experimental colitis.Scientific reports · 2019Article
- Short-chain Fatty Acids Inhibit Staphylococcal Lipoprotein-induced Nitric Oxide Production in Murine Macrophages.Immune network · 2019Article
- The effect of breastfeeding on the risk of asthma in high-risk children: a case-control study in Shanghai, China.BMC pregnancy and childbirth · 2018Article
- Short Chain Fatty Acids in the Colon and Peripheral Tissues: A Focus on Butyrate, Colon Cancer, Obesity and Insulin Resistance.Nutrients · 2017Review
- Nutritional outcomes with implementation of probiotics in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2015Article
- Towards large-cohort comparative studies to define the factors influencing the gut microbial community structure of ASD patients.Microbial ecology in health and disease · 2015Article
- Probiotics prevent necrotizing enterocolitis by modulating enterocyte genes that regulate innate immune-mediated inflammation.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Dietary inhibitors of histone deacetylases in intestinal immunity and homeostasis.Frontiers in immunology · 2013Article
- Nutritional and probiotic supplementation in colitis models.Digestive diseases and sciences · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Inflammatory bowel disease (IBD) is characterized by an exaggerated immune response that involves pro-inflammatory cytokines including IL-8. Production of these pro-inflammatory cytokines is triggered by pathogen-associated molecular patterns (PAMP). Butyrate, a product of bacterial fermentation of carbohydrates, has been reported to modulate inflammation in IBD, possibly by regulating production of pro-inflammatory cytokines. However, this effect of butyrate is controversial. In this study, we used Pam3CSK4 (Pam3CysSerLys4), the acylated NH2-terminus of the bacterial lipoprotein (a PAMP), to mimic in vivo infection of pathogens. Butyrate transiently down-regulated expression of IL-8 stimulated by Pam3CSK4. Treatment of cells with butyrate before Pam3CSK4, however, enhanced production of IL-8. Furthermore, butyrate induced expression of A20, a negative regulator of the nuclear factor-kappaB pathway. Over-expression of A20 inhibited Pam3CSK4-triggered IL-8 expression. Our data suggest that the inflammatory modulation of butyrate in IBD is mediated by A20 and a short pulse rather than continuous administration of butyrate may provide a protective effect on IBD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.