ArticleMolecular biology of the cell2007
Retrograde fluxes of focal adhesion proteins in response to cell migration and mechanical signals.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 92 citations in OpenAlex.
- Article
- Investigating multi-material hydrogel three-dimensional printing forRoyal Society open science · 2023Article
- A luciferase fragment complementation assay to detect focal adhesion kinase (FAK) signaling events.Heliyon · 2023Article
- Phosphoserine-86-HSPB1 (pS86-HSPB1) is cytoplasmic and highly induced in rat myometrium at labour.Histochemistry and cell biology · 2023Article
- The effects of inhibition and siRNA knockdown of collagen-binding integrins on human umbilical vein endothelial cell migration and tube formation.Scientific reports · 2022Article
- Phosphorylation of the small heat shock protein HspB1 regulates cytoskeletal recruitment and cell motility.Molecular biology of the cell · 2022Article
- Large-scale curvature sensing by directional actin flow drives cellular migration mode switching.Nature physics · 2019Article
- Live cell imaging reveals focal adhesions mechanoresponses in mammary epithelial cells under sustained equibiaxial stress.Scientific reports · 2018Article
- Mechanical signals activate p38 MAPK pathway-dependent reinforcement of actin via mechanosensitive HspB1.Molecular biology of the cell · 2017Article
- Actin-Based Adhesion Modules Mediate Cell Interactions with the Extracellular Matrix and Neighboring Cells.Cold Spring Harbor perspectives in biology · 2017Review
- Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres.Nature communications · 2017Article
- Heading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical Environments.Cellular and molecular bioengineering · 2016Review
- LIM proteins in actin cytoskeleton mechanoresponse.Trends in cell biology · 2014Review
- Guiding cell migration by tugging.Current opinion in cell biology · 2013Review
- Requirement of LIM domains for the transient accumulation of paxillin at damaged stress fibres.Biology open · 2013Article
- Mechanotransduction at focal adhesions: from physiology to cancer development.Journal of cellular and molecular medicine · 2013Review
- α-actinin1 and 4 tyrosine phosphorylation is critical for stress fiber establishment, maintenance and focal adhesion maturation.Experimental cell research · 2013Article
- The tension mounts: stress fibers as force-generating mechanotransducers.The Journal of cell biology · 2013Review
- Force mapping during the formation and maturation of cell adhesion sites with multiple optical tweezers.PloS one · 2013Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies suggest that mechanical signals mediated by the extracellular matrix play an essential role in various physiological and pathological processes; yet, how cells respond to mechanical stimuli remains elusive. Using live cell fluorescence imaging, we found that actin filaments, in association with a number of focal adhesion proteins, including zyxin and vasodilator-stimulated phosphoprotein, undergo retrograde fluxes at focal adhesions in the lamella region. This flux is inversely related to cell migration, such that it is amplified in fibroblasts immobilized on micropatterned islands. In addition, the flux is regulated by mechanical signals, including stretching forces applied to flexible substrates and substrate stiffness. Conditions favoring the flux share the common feature of causing large retrograde displacements of the interior actin cytoskeleton relative to the substrate anchorage site, which may function as a switch translating mechanical input into chemical signals, such as tyrosine phosphorylation. In turn, the stimulation of actin flux at focal adhesions may function as part of a feedback mechanism, regulating structural assembly and force production in relation to cell migration and mechanical load. The retrograde transport of associated focal adhesion proteins may play additional roles in delivering signals from focal adhesions to the interior of the cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.