ArticleProceedings of the National Academy of Sciences of the United States of America2007
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 4 of them syntheses that pooled it.
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Who cites it
85 citing papers in PubMed, 4 syntheses or guidelines pooled it, 218 citations in OpenAlex.
- Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysis.International journal of colorectal disease · 2012Pooled it
- Pooled it
- Interleukin-23 receptor genetic polymorphisms and Crohn's disease susceptibility: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Pooled it
- T300A polymorphism of ATG16L1 and susceptibility to inflammatory bowel diseases: a meta-analysis.World journal of gastroenterology · 2010Pooled it
- Frequency enrichment of coding variants in a French-Canadian founder population and its implication for inflammatory bowel diseases.medRxiv : the preprint server for health sciences · 2025Article
- IL23R-Specific CAR Tregs for the Treatment of Crohn's Disease.Journal of Crohn's & colitis · 2025Article
- Haplotype-resolved germline and somatic alterations in renal medullary carcinomas.Genome medicine · 2021Article
- Human intelectin-1 (ITLN1) genetic variation and intestinal expression.Scientific reports · 2021Article
- Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions.PLoS genetics · 2019Article
- Relationship between theInternational journal of environmental research and public health · 2019Article
- Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.Scientific reports · 2018Article
- The Role of Efferocytosis in Autoimmune Diseases.Frontiers in immunology · 2018Review
- Association of miR-21, miR-126 and miR-605 gene polymorphisms with ischemic stroke risk.Oncotarget · 2017Article
- Autophagy-related gene LRRK2 is likely a susceptibility gene for systemic lupus erythematosus in northern Han Chinese.Oncotarget · 2017Article
- Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility.Expert review of clinical immunology · 2016Review
- Gene and Network Analysis of Common Variants Reveals Novel Associations in Multiple Complex Diseases.Genetics · 2016Article
- Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation.Cell reports · 2016Article
- eQTL analysis links inflammatory bowel disease associated 1q21 locus to ECM1 gene.Journal of applied genetics · 2016Article
- New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics.Current neurology and neuroscience reports · 2016Review
- Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.PloS one · 2016Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
25 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide association (GWA) studies offer a powerful unbiased method for the identification of multiple susceptibility genes for complex diseases. Here we report the results of a GWA study for Crohn's disease (CD) using family trios from the Quebec Founder Population (QFP). Haplotype-based association analyses identified multiple regions associated with the disease that met the criteria for genome-wide significance, with many containing a gene whose function appears relevant to CD. A proportion of these were replicated in two independent German Caucasian samples, including the established CD loci NOD2 and IBD5. The recently described IL23R locus was also identified and replicated. For this region, multiple individuals with all major haplotypes in the QFP were sequenced and extensive fine mapping performed to identify risk and protective alleles. Several additional loci, including a region on 3p21 containing several plausible candidate genes, a region near JAKMIP1 on 4p16.1, and two larger regions on chromosome 17 were replicated. Together with previously published loci, the spectrum of CD genes identified to date involves biochemical networks that affect epithelial defense mechanisms, innate and adaptive immune response, and the repair or remodeling of tissue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.