ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
State changes rapidly modulate cortical neuronal responsiveness.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.
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Who cites it
131 citing papers in PubMed.
- A claustro-cortical loop times state transitions for flexible behavior.Research square · 2026Article
- A claustro-cortical loop times state transitions for flexible behavior.bioRxiv : the preprint server for biology · 2026Article
- Live Spike Sorting of Large-scale Neural Recordings.bioRxiv : the preprint server for biology · 2026Article
- Do auditory deviants evoke cortical state changes under anaesthesia? A proof-of-concept study.Experimental physiology · 2026Article
- Timing and Convergence of Ensemble Activity Govern Auditory Thalamocortical Transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Local infrared stimulation modulates spontaneous cortical slow wave dynamics in anesthetized rats.Scientific reports · 2026Article
- Sensory encoding and memory retrieval are coordinated with propagating waves in the human brain.Nature communications · 2026Article
- Cell-intrinsic mechanisms underlying spontaneous activity in the mouse visual cortical slice: implications for fragile X pathophysiology.Journal of neurophysiology · 2026Article
- Sensory Encoding Alternates With Hippocampal Ripples across Cycles of Forebrain Spiking Cascades.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Effects of Phasic Activation of Locus Ceruleus on Cortical Neural Activity and Auditory Discrimination Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Signal switching may enhance processing power of the brain.Trends in cognitive sciences · 2024Review
- Basic Properties of Coordinated Neuronal Ensembles in the Auditory Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Propofol-mediated Unconsciousness Disrupts Progression of Sensory Signals through the Cortical Hierarchy.Journal of cognitive neuroscience · 2024Article
- Stochastic resonance in sparse neuronal network: functional role of ongoing activity to detect weak sensory input in awake auditory cortex of rat.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Intrinsic forebrain arousal dynamics governs sensory stimulus encoding.bioRxiv : the preprint server for biology · 2023Article
- Endogenous fluctuations in cortical state selectively enhance different modes of sensory processing in human temporal lobe.Nature communications · 2023Article
- Unsupervised approach to decomposing neural tuning variability.Nature communications · 2023Article
- Attractor and integrator networks in the brain.Nature reviews. Neuroscience · 2022Review
- Precise movement-based predictions in the mouse auditory cortex.Current biology : CB · 2022Article
71 more citing papers are in PubMed but not listed here.
Corrections and comments
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The responsiveness of cortical neurons is strongly and rapidly influenced by changes in the level of local network activity. In rodent somatosensory cortex, increases in network activity increase neuronal responsiveness to the intracellular injection of brief conductance stimuli but paradoxically decrease responsiveness to brief whisker deflections. However, whisker stimulation frequently evokes long-lasting changes in the level of local circuit activity. The ability of stimuli to successfully evoke prolonged increases in circuit activity is associated with both an increase in the amount of conductance evoked by a whisker stimulus and an increase in action potential responsiveness to whisker stimulation. In addition, brief whisker stimuli presented during periods of high network activity evoke postsynaptic potentials containing a greater proportion of inhibition, consistent with an increased efficiency in the activation of inhibitory mechanisms during the Up state. In contrast, during prolonged and variable whisker stimulation, increased network activity is associated with an increase in overall responsiveness, dynamic range, output gain, and correlation between action potential response and speed of whisker movement. We conclude that stimulus-evoked or spontaneous alterations in cortical state can influence neuronal responsiveness in a complex manner, resulting in large changes in which, and how, sensory stimuli are represented.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.