ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Noradrenergic modulation of subthalamic nucleus activity: behavioral and electrophysiological evidence in intact and 6-hydroxydopamine-lesioned rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Neurotransmitter and receptor systems in the subthalamic nucleus.Brain structure & function · 2023Review
- Acute Colon Inflammation Triggers Primary Motor Cortex Glial Activation, Neuroinflammation, Neuronal Hyperexcitability, and Motor Coordination Deficits.International journal of molecular sciences · 2022Article
- Article
- Influence of Anesthesia and Clinical Variables on the Firing Rate, Coefficient of Variation and Multi-Unit Activity of the Subthalamic Nucleus in Patients with Parkinson's Disease.Journal of clinical medicine · 2020Article
- Targeting the noradrenergic system for anti-inflammatory and neuroprotective effects: implications for Parkinson's disease.Neural regeneration research · 2018Review
- Lead-Induced Atypical Parkinsonism in Rats: Behavioral, Electrophysiological, and Neurochemical Evidence for a Role of Noradrenaline Depletion.Frontiers in neuroscience · 2018Article
- Investigation of Behavioral Dysfunctions Induced by Monoamine Depletions in a Mouse Model of Parkinson's Disease.Frontiers in cellular neuroscience · 2018Article
- Reduced noradrenergic innervation of ventral midbrain dopaminergic cell groups and the subthalamic nucleus in MPTP-treated parkinsonian monkeys.Neurobiology of disease · 2017Article
- Article
- MDMA modulates spontaneous firing of subthalamic nucleus neurons in vitro.Experimental brain research · 2015Article
- Identifying the Basal Ganglia network model markers for medication-induced impulsivity in Parkinson's disease patients.PloS one · 2015Article
- Article
- Inhibiting subthalamic D5 receptor constitutive activity alleviates abnormal electrical activity and reverses motor impairment in a rat model of Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Decomposition of abnormal free locomotor behavior in a rat model of Parkinson's disease.Frontiers in systems neuroscience · 2013Article
- Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease.Progress in neurobiology · 2012Review
- Noradrenaline and Parkinson's disease.Frontiers in systems neuroscience · 2011Article
- Aberrant striatal plasticity is specifically associated with dyskinesia following levodopa treatment.Movement disorders : official journal of the Movement Disorder Society · 2010Article
- Involvement of Basal Ganglia network in motor disabilities induced by typical antipsychotics.PloS one · 2009Article
- Noradrenergic modulation of the motor response induced by long-term levodopa administration in Parkinsonian rats.Journal of neural transmission (Vienna, Austria : 1996) · 2009Article
- Light and electron microscopic localization of alpha-1 adrenergic receptor immunoreactivity in the rat striatum and ventral midbrain.Neuroscience · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The subthalamic nucleus (STN) plays a key role in the pathophysiology of Parkinson's disease. The modulation of the STN by norepinephrine, however, is unknown. The present study aims at characterizing the effects of systemic administration of noradrenergic agents on locomotor activity and on in vivo extracellularly recorded STN neuronal activity in intact and 6-hydroxydopamine (6-OHDA)-lesioned rats. Using selective agonists and antagonists of alpha1 and alpha2 adrenergic receptors (ARs), we show that STN neurons have functional alpha1- and alpha2-AR controlling STN firing with an impact on locomotor activity. We further demonstrate that those systemic effects are supported, at least in part, by a direct modulation of STN neuronal activity, using patch-clamp recordings of STN neurons in brain slices. These findings support the premise that hypokinesia is associated with an increased STN neuronal activity, and that improvements of parkinsonian motor abnormalities are associated with a decrease in STN activity. Our data challenge assumptions about the role of alpha1-AR and alpha2-AR in the regulation of STN neurons in both intact and 6-OHDA-lesioned rats and further ground the rationale for using alpha2-AR noradrenergic antagonists in Parkinson's disease, albeit via an unexpected mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.