ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Axonal neurofilaments control multiple fiber properties but do not influence structure or spacing of nodes of Ranvier.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Loss and recovery of neurofilament in the cat lateral geniculate nucleus following monocular retinal inactivation.Frontiers in neuroscience · 2026Article
- The node of Ranvier influences theiScience · 2024Article
- Article
- Differential effect of an evolving amyloid and tau pathology on brain phospholipids and bioactive lipid mediators in rat models of Alzheimer-like pathology.Journal of neuroinflammation · 2024Article
- Schwann cells are axo-protective after injury irrespective of myelination status in mouse Schwann cell-neuron cocultures.Journal of cell science · 2023Article
- Transcriptomic Profiling after In Vitro ΔPharmaceuticals (Basel, Switzerland) · 2023Article
- The role of neurofilament transport in the radial growth of myelinated axons.Molecular biology of the cell · 2023Article
- New evidence for secondary axonal degeneration in demyelinating neuropathies.Neuroscience letters · 2021Review
- A mechanism for neurofilament transport acceleration through nodes of Ranvier.Molecular biology of the cell · 2020Article
- Local Acceleration of Neurofilament Transport at Nodes of Ranvier.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- End-to-end and end-to-side neurorrhaphy between thick donor nerves and thin recipient nerves: an axon regeneration study in a rat model.Neural regeneration research · 2018Article
- Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system.Scientific reports · 2017Article
- Dynamic Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- N98S mutation in NEFL gene is dominantly inherited with a phenotype of polyneuropathy and cerebellar atrophy.Journal of the neurological sciences · 2016Article
- In vivo observation and biophysical interpretation of time-dependent diffusion in human white matter.NeuroImage · 2016Article
- RBFOX3/NeuN is Required for Hippocampal Circuit Balance and Function.Scientific reports · 2015Article
- Article
- Molecular regulators of nerve conduction - Lessons from inherited neuropathies and rodent genetic models.Experimental neurology · 2015Review
- Subcellular patterning: axonal domains with specialized structure and function.Developmental cell · 2015Review
- Local regulation of neurofilament transport by myelinating cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the vertebrate nervous system, axon calibers correlate positively with myelin sheath dimensions and electrophysiological parameters including action potential amplitude and conduction velocity. Neurofilaments, a prominent component of the neuronal cytoskeleton, are required by axons to support their normal radial growth. To distinguish between fiber features that arise in response to absolute axon caliber and those that are under autonomous control, we investigated transgenic mice in which neurofilaments are sequestered in neuronal cell bodies. The neurofilament deficient axons in such mice achieve mature calibers only 50% of normal and have altered conduction properties. We show here that this primary axonal defect also induces multiple changes in myelin sheath composition and radial dimensions. Remarkably, other fundamental fiber features, including internodal spacing and the architecture and composition of nodes of Ranvier, remain unaltered. Thus, many fiber characteristics are controlled through mechanisms operating independently of absolute axon caliber and the neurofilament cytoskeleton.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.