ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Synaptic kainate receptors tune oriens-lacunosum moleculare interneurons to operate at theta frequency.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49 citing papers in PubMed, 89 citations in OpenAlex.
- Parvalbumin interneurons: the dark and bright sides of a key playmaker of neural circuits and behavior.Frontiers in cellular neuroscience · 2025Review
- Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons.PLoS biology · 2024Article
- Interneuronal GluK1 kainate receptors control maturation of GABAergic transmission and network synchrony in the hippocampus.Molecular brain · 2023Article
- Theta-gamma phase amplitude coupling in a hippocampal CA1 microcircuit.PLoS computational biology · 2023Article
- Hippocampal Somatostatin Interneurons, Long-Term Synaptic Plasticity and Memory.Frontiers in neural circuits · 2021Article
- The Role of Glutamate in Language and Language Disorders - Evidence from ERP and Pharmacologic Studies.Neuroscience and biobehavioral reviews · 2020Review
- Brain-Derived Neurotrophic Factor Val66Met polymorphism interacts with adolescent stress to alter hippocampal interneuron density and dendritic morphology in mice.Neurobiology of stress · 2020Article
- Kainate Receptor Activation Shapes Short-Term Synaptic Plasticity by Controlling Receptor Lateral Mobility at Glutamatergic Synapses.Cell reports · 2020Article
- Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model.Nature communications · 2019Article
- Molecular and Cellular Mechanisms Underlying Somatostatin-Based Signaling in Two Model Neural Networks, the Retina and the Hippocampus.International journal of molecular sciences · 2019Review
- Kainate Receptors Play a Role in Modulating Synaptic Transmission in the Olfactory Bulb.Neuroscience · 2018Article
- Morphological diversity and connectivity of hippocampal interneurons.Cell and tissue research · 2018Review
- Hippocampal GABAergic Inhibitory Interneurons.Physiological reviews · 2017Review
- Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition.Cell reports · 2017Article
- Article
- HIV-1 Tat causes cognitive deficits and selective loss of parvalbumin, somatostatin, and neuronal nitric oxide synthase expressing hippocampal CA1 interneuron subpopulations.Journal of neurovirology · 2016Article
- Diverse roles for ionotropic glutamate receptors on inhibitory interneurons in developing and adult brain.The Journal of physiology · 2016Review
- Serotonin Attenuates Feedback Excitation onto O-LM Interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Different AMPA receptor subtypes mediate the distinct kinetic components of a biphasic EPSC in hippocampal interneurons.Frontiers in synaptic neuroscience · 2015Article
- Membrane potential-dependent integration of synaptic inputs in entorhinal stellate neurons.Hippocampus · 2014Article
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7 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
GABAergic interneurons of the hippocampus play an important role in the generation of behaviorally relevant network oscillations. Among this heterogeneous neuronal population, somatostatin (SOM)-positive oriens-lacunosum moleculare (O-LM) interneurons are remarkable because they are tuned to operate at theta frequencies (6-10 Hz) in vitro and in vivo. Recent studies show that a high proportion of glutamatergic synapses that impinge on O-LM interneurons are mediated by kainate receptors (KA-Rs). In the present study, we thus tested the hypothesis that KA-Rs transmit afferent inputs in O-LM neurons during synaptic stimulation at theta frequency. We combined multibeam two-photon calcium imaging in hippocampal slices from SOM-enhanced green fluorescent protein (EGFP) mice, to record the activity of SOM cells as well as hundreds of neurons simultaneously, and targeted electrophysiological recordings and morphological analysis to describe the morphofunctional features of particular cells. We report that EGFP-positive O-LM neurons are the only subtype of interneuron that reliably follows synaptic stimulation of the alveus in the theta frequency range. Electrophysiological recordings revealed the crucial contribution of KA-Rs to the firing activity and to the glutamatergic response to theta stimuli in O-LM cells compared with other cell types. The reliable activation of O-LM cells in the theta frequency range did not simply result from the longer kinetics of KA-R-mediated postsynaptic events (EPSP(KA)) but presumably from a specific interaction between EPSP(KA) and their intrinsic active membrane properties. Such preferential processing of excitatory inputs via KA-Rs by distally projecting GABAergic microcircuits could provide a key role in theta band frequency oscillations.
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