ReviewArchives of disease in childhood. Fetal and neonatal edition2007
Haematology of Down syndrome.
Review in Archives of disease in childhood. Fetal and neonatal edition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 87 citations in OpenAlex.
- Hematological Indices Abnormalities Among Sudanese Children With Down Syndrome.Health science reports · 2026Article
- Article
- Postoperative evaluation of special needs and healthy patients with endodontic treatment under general anesthesia: a retrospective research.BMC oral health · 2024Article
- Article
- Medical imaging utilization and associated radiation exposure in children with down syndrome.PloS one · 2023Article
- Blood cytology in children with down syndrome.BMC pediatrics · 2022Article
- Article
- Leukemia Risk in a Cohort of 3.9 Million Children with and without Down Syndrome.The Journal of pediatrics · 2021Article
- The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.Nature communications · 2021Article
- Transient abnormal myelopoiesis in pediatrics with trisomy 21.Clinical case reports · 2021Article
- A retrospective study of myeloid leukaemia in children with Down syndrome in Ireland.Irish journal of medical science · 2020Article
- Classification of acute myeloid leukemia.Blood research · 2020Review
- Pathologic Features of Down Syndrome Myelodysplastic Syndrome and Acute Myeloid Leukemia: A Report From the Children's Oncology Group Protocol AAML0431.Archives of pathology & laboratory medicine · 2020Article
- Transient Abnormal Myelopoiesis and AML in Down Syndrome: an Update.Current hematologic malignancy reports · 2016Review
- Role of multiplex reverse-transcriptase PCR for diagnosis of Acute myelosis in an infant with Down's syndrome.Medical journal, Armed Forces India · 2015Article
- Anemia in children with down syndrome.International journal of pediatrics · 2011Article
- Germinal and Somatic Trisomy 21 Mosaicism: How Common is it, What are the Implications for Individual Carriers and How Does it Come About?Current genomics · 2010Article
- Transient abnormal myelopoesis in an infant with Down syndrome.The Libyan journal of medicine · 2010Article
- Hematological abnormalities in adult patients with Down's syndrome.Irish journal of medical science · 2009Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
Down syndrome is a common congenital disorder affecting approximately 1/1000 live births. Newborns and children with Down syndrome may present with many haematological problems. In addition, benign abnormalities of the blood count and blood film, which may manifest at any age, population-based and cancer-based registries and clinical trials suggest there is a approximately 12-fold increased risk of acute lymphoblastic leukaemia in the age group of 5-30 years that rises to approximately 40-fold in children younger than 5 years, and that there is a approximately 150-fold increased risk of acute myeloid leukaemia in children younger than 5 years. There is also a virtually unique predisposition to a transient neonatal leukaemia, known as transient abnormal myelopoiesis. Deaths from leukaemia, in part, account for the excess mortality associated with Down syndrome. This article reviews the clinical presentation and the progress made in the management of these disorders over the past decade. It also briefly considers the recent exciting scientific advances that have potential to transform management of leukaemia in children with Down syndrome and also have implications for management of childhood leukaemia more generally.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.