ArticleMolecular and cellular neurosciences2007
ARHGAP4 is a novel RhoGAP that mediates inhibition of cell motility and axon outgrowth.
Article in Molecular and cellular neurosciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 65 citations in OpenAlex.
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- Dual regulation of the actin cytoskeleton by CARMIL-GAP.Journal of cell science · 2022Article
- Analysis of ARHGAP4 Expression With Colorectal Cancer Clinical Characteristics and Prognosis.Frontiers in oncology · 2022Article
- ARHGAP4-SEPT2-SEPT9 complex enables both up- and down-modulation of integrin-mediated focal adhesions, cell migration, and invasion.Molecular biology of the cell · 2021Article
- Dendritic Spine Initiation in Brain Development, Learning and Diseases and Impact of BAR-Domain Proteins.Cells · 2021Review
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- miR-939-5p Contributes to the Migration and Invasion of Pancreatic Cancer by Targeting ARHGAP4.OncoTargets and therapy · 2020Article
- ARHGAP4 mediates the Warburg effect in pancreatic cancer through the mTOR and HIF-1α signaling pathways.OncoTargets and therapy · 2019Article
- The Sex Chromosome Hypothesis of Schizophrenia: Alive, Dead, or Forgotten? A Commentary and Review.Molecular neuropsychiatry · 2018Article
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- A hypomorphic inherited pathogenic variant in DDX3X causes male intellectual disability with additional neurodevelopmental and neurodegenerative features.Human genomics · 2018Article
- Mind the (sr)GAP - roles of Slit-Robo GAPs in neurons, brains and beyond.Journal of cell science · 2017Review
- Pathway and network-based analysis of genome-wide association studies and RT-PCR validation in polycystic ovary syndrome.International journal of molecular medicine · 2017Article
- Loss of β-PIX inhibits focal adhesion disassembly and promotes keratinocyte motility via myosin light chain activation.Journal of cell science · 2017Article
- Hypoxia is a Key Driver of Alternative Splicing in Human Breast Cancer Cells.Scientific reports · 2017Article
- The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells.Molecular biology of the cell · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
This report examines the structure and function of ARHGAP4, a novel RhoGAP whose structural features make it ideally suited to regulate the cytoskeletal dynamics that control cell motility and axon outgrowth. Our studies show that ARHGAP4 inhibits the migration of NIH/3T3 cells and the outgrowth of hippocampal axons. ARHGAP4 contains an N-terminal FCH domain, a central GTPase activating (GAP) domain and a C-terminal SH3 domain. Our structure/function analyses show that the FCH domain appears to be important for spatially localizing ARHGAP4 to the leading edges of migrating NIH/3T3 cells and to axon growth cones. Our analyses also show that the GAP domain and C-terminus are necessary for ARHGAP4-mediated inhibition of cell and axon motility. These observations suggest that ARHGAP4 can act as a potent inhibitor of cell and axon motility when it is localized to the leading edge of motile cells and axons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.