ArticleVirology2007
Rat coronaviruses infect rat alveolar type I epithelial cells and induce expression of CXC chemokines.
Article in Virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Review
- SDAV, the Rat Coronavirus-How Much Do We Know about It in the Light of Potential Zoonoses.Viruses · 2021Review
- The Current Status and Challenges in the Development of Vaccines and Drugs against Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2).BioMed research international · 2021Review
- Pathology of Coronavirus Infections: A Review of Lesions in Animals in the One-Health Perspective.Animals : an open access journal from MDPI · 2020Review
- Current Perspectives on Coronavirus Disease 2019 and Cardiovascular Disease: A White Paper by theJournal of the American Heart Association · 2020Review
- Associations between immune-suppressive and stimulating drugs and novel COVID-19-a systematic review of current evidence.Ecancermedicalscience · 2020Review
- Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors-The Current Status.Frontiers in immunology · 2020Review
- The Impact of Diabetes Mellitus in COVID-19: A Mechanistic Review of Molecular Interactions.Journal of diabetes research · 2020Review
- Respiratory epithelial cells as master communicators during viral infections.Current clinical microbiology reports · 2019Article
- Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports the murine origin of Betacoronavirus 1 and has implications for the ancestor of Betacoronavirus lineage A.Journal of virology · 2015Article
- Neutrophils are needed for an effective immune response against pulmonary rat coronavirus infection, but also contribute to pathology.The Journal of general virology · 2014Article
- Differentiated phenotypes of primary murine alveolar epithelial cells and their susceptibility to infection by respiratory viruses.Virus research · 2013Article
- Innate immune response of human alveolar type II cells infected with severe acute respiratory syndrome-coronavirus.American journal of respiratory cell and molecular biology · 2013Article
- Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus.Respiratory research · 2012Article
- Virus-infected alveolar epithelial cells direct neutrophil chemotaxis and inhibit their apoptosis.American journal of respiratory cell and molecular biology · 2012Article
- LPS-stimulated cytokine production in type I cells is modulated by the renin-angiotensin system.American journal of respiratory cell and molecular biology · 2012Article
- Article
- Report of the 'mechanisms of lung injury and immunomodulator interventions in influenza' workshop, 21 March 2010, Ventura, California, USA.Influenza and other respiratory viruses · 2011Article
- Rat respiratory coronavirus infection: replication in airway and alveolar epithelial cells and the innate immune response.The Journal of general virology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
We analyzed the ability of two rat coronavirus (RCoV) strains, sialodacryoadenitis virus (SDAV) and Parker's RCoV (RCoV-P), to infect rat alveolar type I cells and induce chemokine expression. Primary rat alveolar type II cells were transdifferentiated into the type I cell phenotype. Type I cells were productively infected with SDAV and RCoV-P, and both live virus and UV-inactivated virus induced mRNA and protein expression of three CXC chemokines: CINC-2, CINC-3, and LIX, which are neutrophil chemoattractants. Dual immunolabeling of type I cells for viral antigen and CXC chemokines showed that chemokines were expressed primarily by uninfected cells. Virus-induced chemokine expression was reduced by the IL-1 receptor antagonist, suggesting that IL-1 produced by infected cells induces uninfected cells to express chemokines. Primary cultures of alveolar epithelial cells are an important model for the early events in viral infection that lead to pulmonary inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.