Evidence map›Paper›PMID 17803596›Full record

ArticlePhotodermatology, photoimmunology & photomedicine2007

Treatment of vitamin D deficiency with UV light in patients with malabsorption syndromes: a case series.

Prakash Chandra, Linda L Wolfenden, Thomas R Ziegler, Junqiang Tian, Menghua Luo, Arlene A Stecenko, Tai C Chen, Michael F Holick, Vin Tangpricha

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Photodermatology, photoimmunology & photomedicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01930539 (Treatment of Vitamin D Deficiency in Intestinal Rehabilitation Clinic Patients With a Portable Ultraviolet B Lamp), which is not on this map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01930539 nacompletednot on this mapstarted 2013, after this paper: background citation

Treatment of Vitamin D Deficiency in Intestinal Rehabilitation Clinic Patients With a Portable Ultraviolet B Lamp

TypeinterventionalSponsorUniversity of NebraskaRan2013 to 2015Enrolled11ConditionsVitamin D Deficiency, Short Bowel SyndromeArmsUltraviolet B lamp
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 81 citations in OpenAlex.

  1. Trial
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  8. Article
  9. A Clinician's guide to vitamin D supplementation for patients with cystic fibrosis.Journal of clinical & translational endocrinology · 2021
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  14. Cystic Fibrosis Pulmonary Exacerbations Attributable to Respiratory Syncytial Virus and Influenza: A Population-Based Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
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  15. Review
  16. Article
  17. Vitamin D for health: a global perspective.Mayo Clinic proceedings · 2013
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Prakash ChandraGraduate Program in Nutrition and Health Sciences and Department of Medicine, Emory University School of Medicine, Atlanta, GA 30307, USA.
Linda L Wolfenden
Thomas R Ziegler
Junqiang Tian
Menghua Luo
Arlene A Stecenko
Tai C Chen
Michael F Holick
Vin Tangpricha
Nutrition Sciences (Belgium) · BEBoston University · USEmory University · US

Funding

Role of T-cells in Osteoporosis in Women Undergoing Surgical MenopauseK23AR054334 · NIAMS · EMORY UNIVERSITY · PI TANGPRICHA, VIN · 2007 to 2011
$641k
NIAMS NIH HHS K23 AR054334
6 · The paper itself

Abstract

backgroundCystic fibrosis (CF) and short bowel syndrome (SBS) patients are unable to absorb vitamin D from the diet and thus are frequently found to be severely vitamin D deficient. We evaluated whether a commercial portable ultraviolet (UV) indoor tanning lamp that has a spectral output that mimics natural sunlight could raise circulating 25-hydroxyvitamin D [25(OH)D] levels in subjects with CF and SBS.

methodsIn initial pilot studies, two SBS subjects came to the outpatient clinic twice weekly for 8 weeks for UV light sessions of 6 min each. In a follow-up study, five CF subjects exposed their lower backs in a seated position to the sunlamp at a distance of 14 cm for 5-10 min depending on the skin type five times a week for 8 weeks. Blood samples for 25(OH)D and parathyroid hormone (PTH) measurements were performed at baseline and at the end of the study.

resultsIn our study, with two SBS subjects, the indoor lamp increased or maintained circulating 25(OH)D levels during the winter months. We increased the UV lamp frequency and found an improved response in the CF patients. Serum 25(OH)D levels in CF subjects at baseline were 21 +/- 3 ng/ml, which increased to 27 +/- 4 ng/ml at the end of 8 weeks (P=0.05). PTH concentration remained largely unchanged in both population groups.

conclusionA UV lamp that emits ultraviolet radiation similar to sunlight and thus produces vitamin D(3) in the skin is an excellent alternative for CF, and SBS patients who suffer from vitamin D deficiency due to fat malabsorption, especially during the winter months when natural sunlight is unable to produce vitamin D3 in the skin. This UV lamp is widely available for commercial home use and could potentially be prescribed to patients with CF or SBS.

Indexed as

PhototherapyAdultCystic FibrosisFemaleHumansMalabsorption SyndromesMaleShort Bowel SyndromeVitamin D Deficiency

Identifiers

PMID17803596
PMCPMC2846322
OpenAlexW2145181501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.