ArticlePLoS biology2007
Autoimmune response as a mechanism for a Dobzhansky-Muller-type incompatibility syndrome in plants.
Article in PLoS biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 268 papers, 1 of them a synthesis that pooled it.
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Who cites it
268 citing papers in PubMed, 1 synthesis or guideline pooled it, 551 citations in OpenAlex.
- Reciprocal responses in the interaction between Arabidopsis and the cell-content-feeding chelicerate herbivore spider mite.Plant physiology · 2014Pooled it
- Graft compatibility emerges from the balance between regeneration and immunity: lessons from plant-plant interactions.Frontiers in plant science · 2026Review
- The molecular evolutionary basis of species formation revisited.Trends in genetics : TIG · 2025Review
- Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis.PLoS genetics · 2025Article
- A semi-dominant NLR allele regulates growth and disease resistance in wheat.Plant biotechnology journal · 2025Article
- DivergingEvolution letters · 2025Article
- A root-specific NLR network mediates immune signaling of resistance genes against plant parasitic nematodes.The Plant cell · 2025Article
- Molecular and physiological basis of heterosis in hybrid rice performance.Molecular breeding : new strategies in plant improvement · 2025Review
- The resistance awakens: Diversity at the DNA, RNA, and protein levels informs engineering of plant immune receptors from Arabidopsis to crops.The Plant cell · 2025Review
- Epidermal electronic-tattoo for plant immune response monitoring.Nature communications · 2025Article
- Genomic structural variation in an alpha/beta hydrolase triggers hybrid necrosis in wheat.Nature communications · 2025Article
- Genome-shock deletion of a hybrid lethality gene breaks a reproductive barrier and facilitates speciation inFrontiers in plant science · 2025Article
- Graft incompatibility between pepper and tomato elicits an immune response and triggers localized cell death.Horticulture research · 2024Article
- The Ecology of Hybrid Incompatibilities.Cold Spring Harbor perspectives in biology · 2024Review
- Article
- Roles of microbiota in autoimmunity in Arabidopsis leaves.Nature plants · 2024Article
- Phenotypic characterization and gene mapping of hybrid necrosis in Triticum durum-Haynaldia villosa amphiploids.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- THB1, a putative transmembrane protein that causes hybrid breakdown in rice.Breeding science · 2024Article
- High allelic diversity in Arabidopsis NLRs is associated with distinct genomic features.EMBO reports · 2024Article
- Graft incompatibility between pepper and tomato can be attributed to genetic incompatibility between diverged immune systems.bioRxiv : the preprint server for biology · 2024Article
208 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Epistatic interactions between genes are a major factor in evolution. Hybrid necrosis is an example of a deleterious phenotype caused by epistatic interactions that is observed in many intra- and interspecific plant hybrids. A large number of hybrid necrosis cases share phenotypic similarities, suggesting a common underlying mechanism across a wide range of plant species. Here, we report that approximately 2% of intraspecific crosses in Arabidopsis thaliana yield F1 progeny that express necrosis when grown under conditions typical of their natural habitats. We show that several independent cases result from epistatic interactions that trigger autoimmune-like responses. In at least one case, an allele of an NB-LRR disease resistance gene homolog is both necessary and sufficient for the induction of hybrid necrosis, when combined with a specific allele at a second locus. The A. thaliana cases provide insights into the molecular causes of hybrid necrosis, and serve as a model for further investigation of intra- and interspecific incompatibilities caused by a simple epistatic interaction. Moreover, our finding that plant immune-system genes are involved in hybrid necrosis suggests that selective pressures related to host-pathogen conflict might cause the evolution of gene flow barriers in plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.