ArticleJapanese journal of cancer research : Gann1991
Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.
Article in Japanese journal of cancer research : Gann, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 36 citations in OpenAlex.
- Activated PyK2 and Its Associated Molecules Transduce Cellular Signaling from the Cancerous Milieu for Cancer Metastasis.International journal of molecular sciences · 2022Review
- Targeted therapies in gastric cancer and future perspectives.World journal of gastroenterology · 2016Review
- Modulation of protein tyrosine phosphorylation in gastric mucosa during re-epithelization processes.World journal of biological chemistry · 2010Article
- Expression and significance of Tie-1 and Tie-2 receptors, and angiopoietins-1, 2 and 4 in colorectal adenocarcinoma: Immunohistochemical analysis and correlation with clinicopathological factors.World journal of gastroenterology · 2005Article
- Altered regulation of Src upon cell detachment protects human lung adenocarcinoma cells from anoikis.Oncogene · 2004Article
- Phosphorylated tyrosine-containing proteins in primary lung cancer correlates with proliferation and prognosis.British journal of cancer · 2002Article
- Tyrosine kinases and gastric cancer.Oncogene · 2000Review
- Role of Src expression and activation in human cancer.Oncogene · 2000Review
- Expression of the Ets-1 proto-oncogene in human gastric carcinoma: correlation with tumor invasion.The American journal of pathology · 1996Article
- Tyrosine phosphorylation of 100-130 kDa proteins in lung cancer correlates with poor prognosis.British journal of cancer · 1996Article
- Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line.British journal of cancer · 1995Article
- Immunohistochemical evaluation of alpha-catenin expression in human gastric cancer.Virchows Archiv : an international journal of pathology · 1994Article
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
Phosphotyrosine-containing proteins in various human cancer cell lines were studied by immunoblotting with anti-phosphotyrosine antibody. Of 29 cell lines derived from oral epidermoid cancer, esophageal cancer, gastric cancer, colon cancer, pancreatic cancer, hepatocellular carcinoma and malignant melanoma, 3 of the 6 gastric cancer cells showed aberrant elevation of tyrosine-specific phosphorylation. On the other hand, both esophageal cancer cells and colon cancer cells, which were reported to have amplified epidermal growth factor receptor and activated p60v-src kinase, respectively, showed no apparent elevation of tyrosine-specific phosphorylation, and their profiles of phosphorylation were similar to that of normal human fibroblasts. Two gastric cancer cells, NUGC-4 and MKN-45, showed similar profiles of phosphorylation but their responses to growth factors differed from each other. Tyrosine phosphorylation in NUGC-4 was strongly activated by treatment with epidermal growth factor and quickly reduced by the acid treatment which is effective in removing growth factors from cellular surface receptors. On the contrary, phosphorylation in MKN-45 did not respond to either growth factor or acid treatment. These results suggest that NUGC-4 and MKN-45 have tyrosine kinases which are activated by different mechanisms but share similar substrates.
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