Evidence map›Paper›PMID 1778756›Full record

ArticleJapanese journal of cancer research : Gann1991

Flow cytometric measurements of somatic cell mutations in Thorotrast patients.

S Umeki, S Kyoizumi, Y Kusunoki, N Nakamura, M Sasaki, T Mori, Y Ishikawa, J B Cologne, M Akiyama

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Japanese journal of cancer research : Gann, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 23 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

S UmekiDepartment of Radiobiology, Radiation Effects Research Foundation, Hiroshima.
S Kyoizumi
Y Kusunoki
N Nakamura
M Sasaki
T Mori
Y Ishikawa
J B Cologne
M Akiyama
Kyoto University · JPRadiation Effects Research Foundation · JPNational Institutes for Quantum Science and Technology · JPThe Cancer Institute Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposure to ionizing radiation has long been well-recognized as a risk factor for cancer development. Since ionizing radiation can induce mutations, an accurate way of measuring somatic mutation frequencies could be a useful tool for evaluating cancer risks. In the present study, we have examined in vivo somatic mutation frequencies at the erythrocyte glycophorin A (GPA) and T-cell receptor (TCR) loci in 18 Thorotrast patients who have been continuously irradiated with alpha-particles emitted from the internal deposition of thorium dioxide and who thus have increased risks of certain malignant tumors. When compared with controls, the results showed a significantly higher frequency of mutants at the lymphocyte TCR loci but not at the erythrocyte GPA loci in the Thorotrast patients. The discrepancy between the results of the two assays is discussed.

Indexed as

AgedAged, 80 and overAntibodies, MonoclonalErythrocytesFlow CytometryGlycophorinsHeterozygoteHumansLymphocytesMaleMutationNeoplasms, Radiation-InducedReceptors, Antigen, T-CellThorium DioxideAntibodies, MonoclonalGlycophorinsReceptors, Antigen, T-CellThorium Dioxide

Identifiers

PMID1778756
PMCPMC5918347
OpenAlexW2065580352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.