ReviewJournal of cellular biochemistry2007
NHERFs, NEP, MAGUKs, and more: interactions that regulate PTEN.
Review in Journal of cellular biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Exploring Phosphatase and Tensin Homologue Deleted on Chromosome Ten (PTEN) as a Potential Therapeutic Target for Cardiac Hypertrophy.ACS pharmacology & translational science · 2025Review
- SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function.EMBO molecular medicine · 2021Article
- In renal cell carcinoma the PTEN splice variant PTEN-Δ shows similar function as the tumor suppressor PTEN itself.Cell communication and signaling : CCS · 2018Article
- Neuropeptide Levels as well as Neprilysin Activity Decrease in Renal Cell Carcinoma.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2016Article
- Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes.Nature cell biology · 2016Article
- MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance.Molecular cell · 2013Article
- Functional analysis of the protein phosphatase activity of PTEN.The Biochemical journal · 2012Article
- Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells.Molecular and cellular biology · 2011Article
- Protein kinases and phosphatases in the control of cell fate.Enzyme research · 2011Article
- PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression.The EMBO journal · 2010Article
- Expression and activity profiles of DPP IV/CD26 and NEP/CD10 glycoproteins in the human renal cancer are tumor-type dependent.BMC cancer · 2010Article
- PTEN and the PI3-kinase pathway in cancer.Annual review of pathology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
This year marks the 10th anniversary of the discovery of the PTEN/MMAC1/TEP1 tumor suppressor gene (hereafter referred to as PTEN), one of the most commonly mutated genes in cancer. PTEN encodes a lipid phosphatase that dephosphorylates phosphoinositide-3,4,5-triphosphate (PIP(3)), thereby counteracting mitogenic signaling pathways driven by phosphoinositol-3-kinases (PI3K). By opposing PI3K signaling, PTEN inhibits the activation of the critical PI3K effector proteins Akt1-3 (also known as protein kinase B or PKB). Given its central role in antagonizing PI3K signaling, one might expect that like PI3K, the activity of the PTEN protein would be highly regulated by numerous protein/protein interactions. However, surprisingly little is known about such interactions. This fact, combined with the generally accepted notion that phosphatases are less exquisitely regulated than kinases, has led to the idea that PTEN may function in a relatively unregulated fashion. Here we review the identities and proposed functions of known PTEN-interacting proteins, and point out avenues of investigation that we hope may be fruitful in identifying important new mechanisms of PTEN regulation in mammalian cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.