ArticleVirchows Archiv : an international journal of pathology2007
Flat DIN 1 (flat epithelial atypia) on core needle biopsy: 63 cases identified retrospectively among 1,751 core biopsies performed over an 8-year period (1992-1999).
Article in Virchows Archiv : an international journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Upgrade Rate of Pure Flat Epithelial Atypia Diagnosed at Core Needle Biopsy: A Systematic Review and Meta-Analysis.Radiology. Imaging cancer · 2021Pooled it
- High-Risk Breast Lesions on Core Biopsy: Rates of Upgrade and Management Recommendations.Surgical pathology clinics · 2025Review
- Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?Current oncology (Toronto, Ont.) · 2022Review
- Flat Epithelial Atypia in Breast Core Needle Biopsies With Radiologic-Pathologic Concordance: Is Excision Necessary?The American journal of surgical pathology · 2020Article
- Flat epithelial atypia in directional vacuum-assisted biopsy of breast microcalcifications: surgical excision may not be necessary.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Flat epithelial atypia: conservative management of patients without residual microcalcifications post-vacuum-assisted breast biopsy.The British journal of radiology · 2018Observational
- Upgrade rates of high-risk breast lesions diagnosed on core needle biopsy: a single-institution experience and literature review.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Review
- Analysis of Clinical and Pathologic Factors of Pure, Flat Epithelial Atypia on Core Needle Biopsy to Aid in the Decision of Excision or Observation.Journal of Cancer · 2016Article
- Article
- Morphological parameters of flat epithelial atypia (FEA) in stereotactic vacuum-assisted needle core biopsies do not predict the presence of malignancy on subsequent surgical excision.Virchows Archiv : an international journal of pathology · 2012Article
- Flat epithelial atypia with and without atypical ductal hyperplasia: to re-excise or not. Results of a 5-year prospective study.Virchows Archiv : an international journal of pathology · 2012Article
- Pure flat epithelial atypia is uncommon in subsequent breast excisions for atypical epithelial proliferation.Cancer science · 2012Article
- Flat epithelial atypia diagnosed on core needle biopsy-Clinical challenge.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2012Article
- Early Breast Cancer Precursor Lesions: Lessons Learned from Molecular and Clinical Studies.Breast care (Basel, Switzerland) · 2010Article
- Columnar cell lesions and subsequent breast cancer risk: a nested case-control study.Breast cancer research : BCR · 2010Article
- Article
- [Practical problems in breast screening. Columnar cell lesions including flat epithelial atypia and lobular neoplasia].Der Pathologe · 2008Review
- Are columnar cell lesions the earliest histologically detectable non-obligate precursor of breast cancer?Virchows Archiv : an international journal of pathology · 2008Review
- Mucocele-like tumor and columnar cell hyperplasia of the breast occurring in a morphologic continuum.Journal of medical case reports · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uniform management of flat DIN 1 (flat epithelial atypia) on core needle biopsy (CNB) concerning surgical excision or clinical follow-up are lacking. In a retrospective review of 1,751 CNB over an 8-year period, we found 63 cases with flat DIN 1 as the most advanced lesion; follow-up was available in 55 cases. Of the 63 patients, 24 had a subsequent biopsy for 15 days to 10 years after the initial CNB, an infiltrating carcinoma was found in nine (14.3%) patients, seven (11.1%) in the ipsilateral, and two (3.2%) in the contralateral breast. Five underwent an excisional biopsy of the ipsilateral breast within less than 3 months of the initial CNB; none had either an invasive or intraepithelial carcinoma. Based on our findings, we consider flat DIN 1 a marker of slightly increased risk for subsequent development of invasive breast carcinoma. When flat DIN 1 is found on CNB as the most advanced lesion after mammographic correlation, an excisional biopsy is not mandatory; however, close follow-up is advised with repeat mammograms for early detection of any clinically occult carcinoma in the vicinity of flat DIN 1 that may have been missed by the CNB.
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