ArticleThe Journal of clinical investigation2007
Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut.
Article in The Journal of clinical investigation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 70 citations in OpenAlex.
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- GB1275, a first-in-class CD11b modulator: rationale for immunotherapeutic combinations in solid tumors.Journal for immunotherapy of cancer · 2021Review
- Irisin supports integrin-mediated cell adhesion of lymphocytes.Biochemistry and biophysics reports · 2021Article
- A CD22-Shp1 phosphatase axis controls integrin βNature immunology · 2021Article
- Efficient homing of antibody-secreting cells to the bone marrow requires RNA-binding protein ZFP36L1.The Journal of experimental medicine · 2021Article
- The Role of Tissue Resident Memory CD4 T Cells in Herpes Simplex Viral and HIV Infection.Viruses · 2021Review
- Exosomal regulation of lymphocyte homing to the gut.Blood advances · 2019Article
- β7 integrins contribute to intestinal tumor growth in mice.PloS one · 2018Article
- A Key Regulator of Cell Adhesion: Identification and Characterization of ImportantMolecular and cellular biology · 2017Article
- CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus.The Journal of clinical investigation · 2017Article
- CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Tuning cell migration: contractility as an integrator of intracellular signals from multiple cues.F1000Research · 2016Review
- Tissue instruction for migration and retention of TRM cells.Trends in immunology · 2015Review
- Structural basis of blocking integrin activation and deactivation for anti-inflammation.Journal of biomedical science · 2015Review
- αIIbβ3: structure and function.Journal of thrombosis and haemostasis : JTH · 2015Review
- T cell-associated α4β7 but not α4β1 integrin is required for the induction and perpetuation of chronic colitis.Mucosal immunology · 2014Article
- Agonist leukadherin-1 increases CD11b/CD18-dependent adhesion via membrane tethers.Biophysical journal · 2013Article
- Tissue-resident memory T cells.Immunological reviews · 2013Review
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8 authors at 2 institutions in 1 country.
Funding
Abstract
Integrin adhesion molecules mediate lymphocyte migration and homing to normal and inflamed tissues. While the ligand-binding activity of integrins is known to be modulated by conformational changes, little is known about how the appropriate balance of integrin adhesiveness is maintained in order to optimize the migratory capacity of lymphocytes in vivo. In this study we examined the regulation of the gut homing receptor alpha4beta7 integrin by manipulating at the germline level an integrin regulatory domain known as adjacent to metal ion-dependent adhesion site (ADMIDAS). ADMIDAS normally serves to raise the activation threshold of alpha4beta7, thereby stabilizing it in the default nonadhesive state. Lymphocytes from knockin beta7 (D146A) mice, which harbor a disrupted ADMIDAS, not only expressed an alpha4beta7 integrin that persistently adhered to mucosal addressin cell adhesion molecule-1 (MAdCAM-1), but also exhibited perturbed cell migration along MAdCAM-1 substrates resulting from improper de-adhesion of the lymphocyte trailing edge. In vivo, aberrantly activated alpha4beta7 enhanced adhesion to Peyer's patch venules, but suppressed lymphocyte homing to the gut, diminishing the capacity of T cells to induce colitis. Our results underscore the importance of a proper balance in the adhesion and de-adhesion of the alpha4beta7 integrin, both for lymphocyte trafficking to the gut and for colitis progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.