ArticlePloS one2007
Segmental duplication implicated in the genesis of inversion 2Rj of Anopheles gambiae.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Chromosomal inversions modulate 3D chromatin interactions and regulatory architecture inResearch square · 2026Article
- Chromosomal Inversions and Their Potential Impact on the Evolution of Arboviral Vector Aedes aegypti.Genome biology and evolution · 2025Article
- Two Nested Inversions in the X Chromosome Differentiate the Dominant Malaria Vectors in Europe,Insects · 2024Article
- The Impact of Chromosomal Rearrangements in Speciation: From Micro- to Macroevolution.Cold Spring Harbor perspectives in biology · 2023Review
- Molecular characterization and genetic authentication assay for Anopheles 'hemocyte-like' cell lines 4a-3A and 4a-3B.Parasites & vectors · 2022Article
- Article
- In Silico Karyotyping of Chromosomally Polymorphic Malaria Mosquitoes in theG3 (Bethesda, Md.) · 2019Article
- Inversions are bigger on the X chromosome.Molecular ecology · 2019Article
- Origin and Consequences of Chromosomal Inversions in the virilis Group of Drosophila.Genome biology and evolution · 2018Article
- Article
- Low prevalence of Plasmodium and absence of malaria transmission in Conakry, Guinea: prospects for elimination.Malaria journal · 2016Article
- Endogenous siRNAs and piRNAs derived from transposable elements and genes in the malaria vector mosquito Anopheles gambiae.BMC genomics · 2015Article
- A high resolution map of mammalian X chromosome fragile regions assessed by large-scale comparative genomics.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- Adaptation through chromosomal inversions in Anopheles.Frontiers in genetics · 2014Review
- Segmental duplication, microinversion, and gene loss associated with a complex inversion breakpoint region in Drosophila.Molecular biology and evolution · 2012Article
- Gene alterations at Drosophila inversion breakpoints provide prima facie evidence for natural selection as an explanation for rapid chromosomal evolution.BMC genomics · 2012Article
- Arm-specific dynamics of chromosome evolution in malaria mosquitoes.BMC evolutionary biology · 2011Article
- Breakpoint structure of the Anopheles gambiae 2Rb chromosomal inversion.Malaria journal · 2010Article
- Article
- The transposon Galileo generates natural chromosomal inversions in Drosophila by ectopic recombination.PloS one · 2009Article
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Authors and funding
9 authors.
Funding
Abstract
The malaria vector Anopheles gambiae maintains high levels of inversion polymorphism that facilitate its exploitation of diverse ecological settings across tropical Africa. Molecular characterization of inversion breakpoints is a first step toward understanding the processes that generate and maintain inversions. Here we focused on inversion 2Rj because of its association with the assortatively mating Bamako chromosomal form of An. gambiae, whose distinctive breeding sites are rock pools beside the Niger River in Mali and Guinea. Sequence and computational analysis of 2Rj revealed the same 14.6 kb insertion between both breakpoints, which occurred near but not within predicted genes. Each insertion consists of 5.3 kb terminal inverted repeat arms separated by a 4 kb spacer. The insertions lack coding capacity, and are comprised of degraded remnants of repetitive sequences including class I and II transposable elements. Because of their large size and patchwork composition, and as no other instances of these insertions were identified in the An. gambiae genome, they do not appear to be transposable elements. The 14.6 kb modules inserted at both 2Rj breakpoint junctions represent low copy repeats (LCRs, also called segmental duplications) that are strongly implicated in the recent (approximately 0.4N(e) generations) origin of 2Rj. The LCRs contribute to further genome instability, as demonstrated by an imprecise excision event at the proximal breakpoint of 2Rj in field isolates.
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