ArticlePloS one2007
CCR5 haplotypes and mother-to-child HIV transmission in Malawi.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- The Influence BetweenAIDS research and human retroviruses · 2023Review
- Understanding Viral and Immune Interplay During Vertical Transmission of HIV: Implications for Cure.Frontiers in immunology · 2021Review
- Host Molecular Factors and Viral Genotypes in the Mother-to-Child HIV-1 Transmission in Sub-Saharan Africa.Journal of public health in Africa · 2017Review
- Influence of CCR5 and CCR2 genetic variants in the resistance/susceptibility to HIV in serodiscordant couples from Colombia.AIDS research and human retroviruses · 2013Article
- Naturally-occurring genetic variants in human DC-SIGN increase HIV-1 capture, cell-transfer and risk of mother-to-child transmission.PloS one · 2012Article
- Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians.Retrovirology · 2011Article
- Concordance of CCR5 genotypes that influence cell-mediated immunity and HIV-1 disease progression rates.The Journal of infectious diseases · 2011Article
- Host factors that influence mother-to-child transmission of HIV-1: genetics, coinfections, behavior and nutrition.Future virology · 2011Article
- A haplotype in the CCR5 gene promoter was associated with the susceptibility to HIV-1 infection in a northern Chinese population.Molecular biology reports · 2011Article
- CCR5, RANTES and SDF-1 polymorphisms and mother-to-child HIV-1 transmission.International journal of immunogenetics · 2010Article
- Congenital toxoplasmosis: candidate host immune genes relevant for vertical transmission and pathogenesis.Genes and immunity · 2010Review
- Regulation of CCR5 expression in human placenta: insights from a study of mother-to-child transmission of HIV in Malawi.PloS one · 2010Article
- A whole genome association study of mother-to-child transmission of HIV in Malawi.Genome medicine · 2010Article
- Functional genetic variants in DC-SIGNR are associated with mother-to-child transmission of HIV-1.PloS one · 2009Article
- CCR2-64I polymorphism is associated with lower maternal HIV-1 viral load and reduced vertical HIV-1 transmission.Journal of acquired immune deficiency syndromes (1999) · 2009Article
- Host genetic determinants of human immunodeficiency virus infection and disease progression in children.Pediatric research · 2009Review
- Associations of chemokine receptor polymorphisms With HIV-1 mother-to-child transmission in sub-Saharan Africa: possible modulation of genetic effects by antiretrovirals.Journal of acquired immune deficiency syndromes (1999) · 2008Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundCCR5 and CCR2 gene polymorphisms (SNPs) have been associated with protection against HIV transmission in adults and with delayed progression to AIDS. The CCR5 Delta32 deletion and SNP -2459G are associated with reduced expression of the CCR5 protein. METHODOLOGY/PRINCIPAL
findingsWe investigated the association between infant CCR2/CCR5 diplotype and HIV mother to child transmission (MTCT) in Malawi. Blood samples from infants (n = 552) of HIV positive women who received nevirapine were genotyped using a post-PCR multiplex ligase detection reaction and haplotypes were identified based on 8 CCR2/CCR5 SNPs and the open reading frame 32 base pair deletion. Following verification of Hardy-Weinberg equilibrium, log linear regression was performed to examine the association between mutations and MTCT. Overall, protection against MTCT was weakly associated with two CCR5 SNPs, -2459G (Risk ratio [RR], 0.78; confidence interval [CI], 0.54-1.12), and the linked CCR5 -2135T (RR, 0.78; CI, 0.54-1.13). No child carried the CCR5 Delta32 SNP. Maternal Viral Load (MVL) was found to be an effect measure modifier. Among mothers with low MVL, statistically significant protection against MTCT was observed for -2459G (RR, 0.50; CI, 0.27-0.91), and -2135T (RR, 0.51; CI, 0.28-0.92). Statistically significant protection was not found at high MVL. CONCLUSIONS/SIGNIFICANCE: Results from this study suggest that CCR5 SNPs -2459G and -2135T associated with reduced receptor expression protect against MTCT of HIV at low MVLs, whereas high MVLs may over-ride differences in coreceptor availability.
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