ArticlePloS one2007
An outbreak of severe infections with community-acquired MRSA carrying the Panton-Valentine leukocidin following vaccination.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Contamination and antimicrobial resistance testing ofOpen veterinary journal · 2025Article
- Diversity and Dissemination of Methicillin-ResistantTropical medicine and infectious disease · 2022Review
- Prevalence and Characterization of Food-Related Methicillin-ResistantFrontiers in microbiology · 2019Article
- Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology.Clinical microbiology reviews · 2018Review
- Prevalence and Characterization ofFrontiers in microbiology · 2018Article
- Article
- Prevalence and risk factors of community-associated methicillin-resistantClinical epidemiology · 2018Review
- High Prevalence of Multidrug-Resistant Community-Acquired Methicillin-Resistant Staphylococcus aureus at the Largest Veterinary Teaching Hospital in Costa Rica.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2017Article
- Sepsis, parenteral vaccination and skin disinfection.Human vaccines & immunotherapeutics · 2016Review
- Population structure of colonizing and invasiveJournal of medical microbiology · 2016Article
- Community-associated methicillin-resistant Staphylococcus aureus in non-outbreak skin infections.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
- Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic.Clinical microbiology reviews · 2010Review
- Genetic variation in Staphylococcus aureus surface and immune evasion genes is lineage associated: implications for vaccine design and host-pathogen interactions.BMC microbiology · 2010Article
- Differentiation of clonal complex 59 community-associated methicillin-resistant Staphylococcus aureus in Western Australia.Antimicrobial agents and chemotherapy · 2010Article
- Emergence of community-associated methicillin-resistant Staphylococcus aureus associated with pediatric infection in Cambodia.PloS one · 2009Article
- Biogeography and virulence of Staphylococcus aureus.PloS one · 2009Article
- The role of virulence determinants in community-associated MRSA pathogenesis.Trends in microbiology · 2008Review
- MRSA carriage among healthcare workers in a Vietnamese intensive care unit: a prospective cohort study.Drug target insightsArticle
Corrections and comments
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Authors and funding
29 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundInfections with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) are emerging worldwide. We investigated an outbreak of severe CA-MRSA infections in children following out-patient vaccination. METHODS AND
findingsWe carried out a field investigation after adverse events following immunization (AEFI) were reported. We reviewed the clinical data from all cases. S. aureus recovered from skin infections and from nasal and throat swabs were analyzed by pulse-field gel electrophoresis, multi locus sequence typing, PCR and microarray. In May 2006, nine children presented with AEFI, ranging from fatal toxic shock syndrome, necrotizing soft tissue infection, purulent abscesses, to fever with rash. All had received a vaccination injection in different health centres in one District of Ho Chi Minh City. Eight children had been vaccinated by the same health care worker (HCW). Deficiencies in vaccine quality, storage practices, or preparation and delivery were not found. Infection control practices were insufficient. CA-MRSA was cultured in four children and from nasal and throat swabs from the HCW. Strains from children and HCW were indistinguishable. All carried the Panton-Valentine leukocidine (PVL), the staphylococcal enterotoxin B gene, the gene complex for staphylococcal-cassette-chromosome mec type V, and were sequence type 59. Strain HCM3A is epidemiologically unrelated to a strain of ST59 prevalent in the USA, although they belong to the same lineage.
conclusionsWe describe an outbreak of infections with CA-MRSA in children, transmitted by an asymptomatic colonized HCW during immunization injection. Consistent adherence to injection practice guidelines is needed to prevent CA-MRSA transmission in both in- and outpatient settings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.