ArticleJournal of immunology (Baltimore, Md. : 1950)2007
The role of B cells in the development of CD4 effector T cells during a polarized Th2 immune response.
Article in Journal of immunology (Baltimore, Md. : 1950), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 71 citations in OpenAlex.
- NK cell-derived IFNγ mobilizes free fatty acids from adipose tissue to promote early B cell activation during viral infection.Nature metabolism · 2025Article
- Anti-CD20 treatment attenuates Th2 cell responses: implications for the role of lung follicular mature B cells in the asthmatic mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- In vitro immunoregulatory role of recombinant Ancylostoma ceylanicum calreticulin.Parasites, hosts and diseases · 2024Article
- Initiation of type 2 immunity at barrier surfaces.Mucosal immunology · 2023Review
- Information flow in the spatiotemporal organization of immune responses.Immunological reviews · 2022Review
- Immune pathogenesis in pigeons during experimentalFrontiers in veterinary science · 2022Article
- Involvement of B cells in the development of systemic sclerosis.Frontiers in immunology · 2022Review
- B Cell IL-4 Drives Th2 ResponsesFrontiers in immunology · 2022Article
- Context-dependent roles of B cells during intestinal helminth infection.PLoS neglected tropical diseases · 2021Review
- Potential role of viral infection and B cells as a linker between innate and adaptive immune response in systemic lupus erythematosus.Immunologic research · 2021Article
- Review
- Compartmentalization of dendritic cell and T-cell interactions in the lymph node: Anatomy of T-cell fate decisions.Immunological reviews · 2019Review
- The Essential Role Played by B Cells in Supporting Protective Immunity AgainstFrontiers in immunology · 2019Article
- Immunity to gastrointestinal nematode infections.Mucosal immunology · 2018Review
- Eicosanoid Control Over Antigen Presenting Cells in Asthma.Frontiers in immunology · 2018Review
- Type 2 cytokine responses: regulating immunity to helminth parasites and allergic inflammation.Current pharmacology reports · 2017Article
- B cell-derived IL-4 acts on podocytes to induce proteinuria and foot process effacement.JCI insight · 2017Article
- IL-4-producing B cells regulate T helper cell dichotomy in type 1- and type 2-controlled diseases.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Heterogeneity of Phenotype and Function Reflects the Multistage Development of T Follicular Helper Cells.Frontiers in immunology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies have suggested that B cells promote Th2 cell development by inhibiting Th1 cell differentiation. To examine whether B cells are directly required for the development of IL-4-producing T cells in the lymph node during a highly polarized Th2 response, B cell-deficient and wild-type mice were inoculated with the nematode parasite, Nippostrongylus brasiliensis. On day 7, in the absence of increased IFN-gamma, IL-4 protein and gene expression from CD4 T cells in the draining lymph nodes were markedly reduced in B cell-deficient mice and could not be restored by multiple immunizations. Using a DO11.10 T cell adoptive transfer system, OVA-specific T cell IL-4 production and cell cycle progression, but not cell surface expression of early activation markers, were impaired in B cell-deficient recipient mice following immunization with N. brasiliensis plus OVA. Laser capture microdissection and immunofluorescent staining showed that pronounced IL-4 mRNA and protein secretion by donor DO11.10 T cells first occurred in the T cell:B cell zone of the lymph node shortly after inoculation of IL-4-/- recipients, suggesting that this microenvironment is critical for initial Th2 cell development. Reconstitution of B cell-deficient mice with wild-type naive B cells, or IL-4-/- B cells, substantially restored Ag-specific T cell IL-4 production. However, reconstitution with B7-1/B7-2-deficient B cells failed to rescue the IL-4-producing DO11.10 T cells. These results suggest that B cells, expressing B7 costimulatory molecules, are required in the absence of an underlying IFN-gamma-mediated response for the development of a polarized primary Ag-specific Th2 response in vivo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.