ArticleGenes & development2007
A tDNA establishes cohesion of a neighboring silent chromatin domain.
Article in Genes & development, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 48 citations in OpenAlex.
- Blocking heterochromatin spreading constrains cohesin binding at a yeast heterochromatic locus.PloS one · 2026Article
- Loops and the activity of loop extrusion factors constrain chromatin dynamics.Molecular biology of the cell · 2023Article
- Extrusion of chromatin loops by a composite loop extrusion factor.Physical review. E · 2021Article
- Noncanonical Roles of tRNAs: tRNA Fragments and Beyond.Annual review of genetics · 2020Review
- tRNA Genes Affect Chromosome Structure and Function via Local Effects.Molecular and cellular biology · 2019Article
- Binding, sliding, and function of cohesin during transcriptional activation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae.Genetics · 2016Review
- Determinants of Sir2-Mediated, Silent Chromatin Cohesion.Molecular and cellular biology · 2016Article
- A novel tRNA variable number tandem repeat at human chromosome 1q23.3 is implicated as a boundary element based on conservation of a CTCF motif in mouse.Nucleic acids research · 2014Article
- Coordination of tRNA transcription with export at nuclear pore complexes in budding yeast.Genes & development · 2014Article
- Silencing near tRNA genes is nucleosome-mediated and distinct from boundary element function.Gene · 2013Article
- Long-range heterochromatin association is mediated by silencing and double-strand DNA break repair proteins.The Journal of cell biology · 2013Article
- Genome-wide analysis of functional sirtuin chromatin targets in yeast.Genome biology · 2013Article
- The ancient and evolving roles of cohesin in gene expression and DNA repair.Current biology : CB · 2012Review
- Human tRNA genes function as chromatin insulators.The EMBO journal · 2012Article
- Autoregulation of an RNA polymerase II promoter by the RNA polymerase III transcription factor III C (TF(III)C) complex.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Targeted sister chromatid cohesion by Sir2.PLoS genetics · 2011Article
- A cis-acting tRNA gene imposes the cell cycle progression requirement for establishing silencing at the HMR locus in yeast.Genetics · 2011Article
- Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription.Cell cycle (Georgetown, Tex.) · 2010Review
- Insulators and promoters: closer than we think.Nature reviews. Genetics · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
DNA replication generates sister chromatid pairs that are bound to one another until anaphase onset. The process, termed sister chromatid cohesion, requires the multisubunit cohesin complex that resides at centromeres and sites where genes converge. At the HMR mating-type locus of budding yeast, cohesin associates with a heterochromatin-like structure known as silent chromatin. In this report, we show that silent chromatin is necessary but not sufficient for cohesion of the replicating locus. A tRNA gene (tDNA) that delimits the silent chromatin domain is also required, as are subunits of the TFIIIB and RSC complexes that bind the gene. Non-tDNA boundary elements do not substitute for tDNAs in cohesion, suggesting that barrier activity is not responsible for the phenomenon. The results reveal an unexpected role for tDNAs and RNA polymerase III-associated proteins in establishment of sister chromatid cohesion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.