ArticleMolecular and cellular biology2007
Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Myocyte Enhancer Factor 2A Plays a Central Role in the Regulatory Networks of Cellular Physiopathology.Aging and disease · 2023Review
- Mapping genetic variants for cranial vault shape in humans.PloS one · 2018Article
- NLK-mediated phosphorylation of HDAC1 negatively regulates Wnt signaling.Molecular biology of the cell · 2017Article
- WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway.FEBS letters · 2016Article
- Selective inhibition of the kinase DYRK1A by targeting its folding process.Nature communications · 2016Article
- Article
- Association of nuclear-localized Nemo-like kinase with heat-shock protein 27 inhibits apoptosis in human breast cancer cells.PloS one · 2014Article
- Transcriptional regulation of mesoderm genes by MEF2D during early Xenopus development.PloS one · 2013Article
- NLK is a key regulator of proliferation and migration in gallbladder carcinoma cells.Molecular and cellular biochemistry · 2012Article
- Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning.The EMBO journal · 2012Article
- Homodimerization of Nemo-like kinase is essential for activation and nuclear localization.Molecular biology of the cell · 2011Article
- Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.Nature communications · 2010Article
- Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 mitogen-activated protein kinase.Molecular and cellular biology · 2010Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of anterior neural structure in Xenopus laevis requires the inhibition of bone morphogenic protein 4 and Wnt signaling. We previously reported that Nemo-like kinase (NLK) negatively regulates Wnt signaling via the phosphorylation of T-cell factor/lymphoid enhancer factor. However, the molecular events occurring downstream of NLK pathways in early neural development remain unclear. In the present study, we identified the transcription factor myocyte enhancer factor 2A (MEF2A) as a novel substrate for NLK. NLK regulates the function of Xenopus MEF2A (xMEF2A) via phosphorylation, and this modification can be inhibited by the depletion of endogenous NLK. In Xenopus embryos, the depletion of either NLK or MEF2A results in a severe defect in anterior development. The endogenous expression of anterior markers was blocked by the depletion of endogenous Xenopus NLK (xNLK) or xMEF2A but, notably, not by the depletion of other xMEF2 family proteins, xMEF2C and xMEF2D. Defects in head formation or the expression of the anterior marker genes caused by the depletion of endogenous xMEF2A could be eliminated by the expression of wild-type xMEF2A, but not xMEF2A containing mutated xNLK phosphorylation sites. Furthermore, the expression of xNLK-induced anterior markers was efficiently blocked by the depletion of endogenous xMEF2A in animal pole explants. These results show that NLK specifically regulates the MEF2A activity required for anterior formation in Xenopus development.
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