ArticleProceedings of the National Academy of Sciences of the United States of America2007
Osteopontin regulates hindlimb-unloading-induced lymphoid organ atrophy and weight loss by modulating corticosteroid production.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 73 citations in OpenAlex.
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- Long-term space missions' effects on the human organism: what we do know and what requires further research.Frontiers in physiology · 2024Review
- Unloading-Induced Skeletal Interoception Alters Hypothalamic Signaling to Promote Bone Loss and Fat Metabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- A mouse model of disuse osteoporosis based on a movable noninvasive 3D-printed unloading device.Journal of orthopaedic translation · 2022Article
- Mechanisms of lymphoid depletion in bowel obstruction.Frontiers in physiology · 2022Article
- Transcriptional responses of skeletal stem/progenitor cells to hindlimb unloading and recovery correlate with localized but not systemic multi-systems impacts.NPJ microgravity · 2021Article
- Article
- Simultaneous exposure to chronic irradiation and simulated microgravity differentially alters immune cell phenotype in mouse thymus and spleen.Life sciences in space research · 2021Article
- The Immunomodulatory Effect of Radiofrequency Electromagnetic Field on Serum Cytokine Levels in A Mouse Model of Hindlimb Unloading.Cell journal · 2021Article
- The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2021Article
- Infection-Associated Thymic Atrophy.Frontiers in immunology · 2021Review
- Influence of Microgravity on Apoptosis in Cells, Tissues, and Other Systems In Vivo and In Vitro.International journal of molecular sciences · 2020Review
- RNA sequencing (RNA-seq) analysis of gene expression provides new insights into hindlimb unloading-induced skeletal muscle atrophy.Annals of translational medicine · 2020Article
- Microgravity versus Microgravity and Irradiation: Investigating the Change of Neuroendocrine-Immune System and the Antagonistic Effect of Traditional Chinese Medicine Formula.BioMed research international · 2020Article
- Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight.Scientific reports · 2019Article
- Down-regulation of GATA1-dependent erythrocyte-related genes in the spleens of mice exposed to a space travel.Scientific reports · 2019Article
- PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Influence of Social Isolation During Prolonged Simulated Weightlessness by Hindlimb Unloading.Frontiers in physiology · 2019Article
- Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice.International journal of molecular sciences · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteopontin (OPN), a multifunctional secreted phosphoglycoprotein, plays diverse roles in bone biology, immune regulation, cell survival, inflammation, and cancer metastasis. Here we show its role in determining lymphocyte homeostasis and body mass in response to hindlimb unloading (HU), a model for evaluating effects of weightlessness on the musculoskeletal and other physiological systems. Using this stress model, we compared OPN(-/-) mice with OPN(+/+) mice subjected to HU for 3 days. Whereas OPN(+/+) mice suffered a marked reduction of body weight and significant spleen and thymus atrophy, OPN(-/-) mice exhibited minor weight loss and much less spleen and thymus atrophy. The HU-induced lymphoid organ atrophy was the result of dramatically diminished numbers, respectively, of T and B cells in the spleen and CD4(+)CD8(+) double-positive cells in the thymus of OPN(+/+) mice. Increased levels of corticosterone, which modulates lymphocyte activation responses and apoptosis during stress, were found only in OPN(+/+) mice. Apoptotic cell death was evident in the spleen and thymus of OPN(+/+) mice subjected to HU but not in OPN(-/-)mice. Importantly, lymphocytes from both OPN(+/+) and OPN(-/-) mice were equally sensitive to corticosteroid-induced apoptosis. These results reveal that OPN is required for enhanced corticosterone production, immune organ atrophy, and weight loss in mice subjected to HU.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.