ArticleMolecular microbiology2007
Mycoplasma genitalium: an efficient strategy to generate genetic variation from a minimal genome.
Article in Molecular microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 63 citations in OpenAlex.
- Trial
- Epidemiology and Molecular Characterization of Mycoplasmosis in Northeastern Part of Italy, 2023.Pathogens (Basel, Switzerland) · 2026Article
- JMM Profile:Journal of medical microbiology · 2025Review
- Pathogenicity and virulence ofVirulence · 2022Review
- The mechanisms underlying antigenic variation and maintenance of genomic integrity in Mycoplasma pneumoniae and Mycoplasma genitalium.Archives of microbiology · 2021Review
- Alternative conformation of the C-domain of the P140 protein from Mycoplasma genitalium.Acta crystallographica. Section F, Structural biology communications · 2020Article
- Article
- Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors.Nature communications · 2018Article
- Activation of σ20-dependent recombination and horizontal gene transfer in Mycoplasma genitalium.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- Prevalence ofGerms · 2018Article
- Mycoplasma genitalium: whole genome sequence analysis, recombination and population structure.BMC genomics · 2017Article
- The Unique Microbiology and Molecular Pathogenesis of Mycoplasma genitalium.The Journal of infectious diseases · 2017Review
- Experimental Infection of Pig-Tailed Macaques (Macaca nemestrina) with Mycoplasma genitalium.Infection and immunity · 2017Article
- Inter- and intra-strain variability of tandem repeats in Mycoplasma pneumoniae based on next-generation sequencing data.Future microbiology · 2017Article
- Potential Molecular Targets for Narrow-Spectrum Agents to Combat Mycoplasma pneumoniae Infection and Disease.Frontiers in microbiology · 2016Review
- Kinetics of Genetic Variation of the Mycoplasma genitalium MG192 Gene in Experimentally Infected Chimpanzees.Infection and immunity · 2015Article
- A novel sigma factor reveals a unique regulon controlling cell-specific recombination in Mycoplasma genitalium.Nucleic acids research · 2015Article
- Article
- Mini-review: Strategies for Variation and Evolution of Bacterial Antigens.Computational and structural biotechnology journal · 2015Review
- MG428 is a novel positive regulator of recombination that triggers mgpB and mgpC gene variation in Mycoplasma genitalium.Molecular microbiology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Mycoplasma genitalium, a human pathogen associated with sexually transmitted diseases, is unique in that it has smallest genome of any known free-living organism. The goal of this study was to investigate if and how M. genitalium uses a minimal genome to generate genetic variations. We analysed the sequence variability of the third gene (MG192 or mgpC) of the M. genitalium MgPa adhesion operon, demonstrated that the MG192 gene is highly variable among and within M. genitalium strains in vitro and in vivo, and identified MG192 sequence shifts in the course of in vitro passage of the G37 type strain and in sequential specimens from an M. genitalium-infected patient. In order to establish the origin of the MG192 variants, we examined nine genomic loci containing partial copies of the MgPa operon, known as MgPar sequences. Our analysis suggests that the MG192 sequence variation is achieved by recombination between the MG192 expression site and MgPar sequences via gene cross-over and, possibly, also by gene conversion. It appears plausible that M. genitalium has the ability to generate unlimited variants from its minimized genome, which presumably allows the organism to adapt to diverse environments and/or to evade host defences by antigenic variation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.