Evidence map›Paper›PMID 17768644›Full record

ReviewDer Nervenarzt2007

[Genetics of anxiety disorders. Current clinical and molecular research].

K Domschke, J Deckert

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Der Nervenarzt, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Anxiety disorders].Der Internist · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

K DomschkeKlinik und Poliklinik für Psychiatrie und Psychotherapie, Westfälische Wilhelms-Universität, Münster.
J Deckert

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The authors give an overview of the present state of knowledge on the genetics of anxiety disorders. According to ICD-10 or DSM III/IV classification, anxiety disorders comprise panic disorder, generalized anxiety, phobias, and post-traumatic stress disorder. In the context of the conceptual change from psychodynamic anxiety neuroses to complex, multifactorial anxiety disorders, a summary of biological hypotheses of the pathogenesis of anxiety derived from pharmacotherapy, challenge tests, and animal model disorders is provided. The relevant findings from clinical genetic studies (twin and family) and molecular genetic studies (linkage and association) are presented in detail. The most data now available are on panic disorder, though with regard to molecular genetics these are still preliminary. In addition, genetic findings on anxiety as a personality dimension are reviewed, taking into account the present phenotype discussion (category vs dimension). Finally, ethical and therapeutic implications of genetic research on complex, polygenic disorders are discussed.

Indexed as

Anxiety DisordersBiomedical ResearchGenetic Predisposition to DiseaseGenetic TherapyHumansModels, GeneticModels, NeurologicalMolecular Biology

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.