ArticleAtherosclerosis2008
A pleiotropic QTL on 2p influences serum Lp-PLA2 activity and LDL cholesterol concentration in a baboon model for the genetics of atherosclerosis risk factors.
Article in Atherosclerosis, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- The baboon kidney transcriptome: analysis of transcript sequence, splice variants, and abundance.PloS one · 2013Article
- Baboons as a model to study genetics and epigenetics of human disease.ILAR journal · 2013Review
- The value of extended pedigrees for next-generation analysis of complex disease in the rhesus macaque.ILAR journal · 2013Review
- Sex-specific heritability of spontaneous lipid levels in an extended pedigree of Indian-origin rhesus macaques (Macaca mulatta).PloS one · 2013Article
- Effects of diet on genetic regulation of lipoprotein metabolism in baboons.Atherosclerosis · 2010Article
- Assisted Reproductive Technologies (ART) with baboons generate live offspring: a nonhuman primate model for ART and reproductive sciences.Reproductive sciences (Thousand Oaks, Calif.) · 2010Article
- Comparative analyses of single-nucleotide polymorphisms in the TNF promoter region provide further validation for the vervet monkey model of obesity.Comparative medicine · 2009Article
- Integration of genetic and genomic methods for identification of genes and gene variants encoding QTLs in the nonhuman primate.Methods (San Diego, Calif.) · 2009Article
- Localization of multiple pleiotropic genes for lipoprotein metabolism in baboons.Journal of lipid research · 2009Article
- Genotype-by-diet effects on co-variation in Lp-PLA2 activity and LDL-cholesterol concentration in baboons fed an atherogenic diet.Journal of lipid research · 2008Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), the major portion of which is bound to low-density lipoprotein, is an independent biomarker of cardiovascular disease risk. To search for common genetic determinants of variation in both Lp-PLA(2) activity and LDL cholesterol (LDL-C) concentration, we assayed these substances in serum from 679 pedigreed baboons. Using a maximum likelihood-based variance components approach, we detected significant evidence for a QTL affecting Lp-PLA(2) activity (LOD=2.79, genome-wide P=0.039) and suggestive evidence for a QTL affecting LDL-C levels (LOD=2.16) at the same location on the baboon ortholog of human chromosome 2p. Because we also found a significant genetic correlation between the two traits (rho(G)=0.50, P<0.00001), we conducted bivariate linkage analyses of Lp-PLA(2) activity and LDL-C concentration. These bivariate analyses improved the evidence (LOD=3.19, genome-wide P=0.015) for a QTL at the same location on 2p, corresponding to the human cytogenetic region 2p24.3-p23.2. The QTL-specific correlation between the traits (rho(Q)=0.62) was significantly different from both zero and 1 (P[rho(Q)=0]=0.047; P[rho(Q)=1]=0.022), rejecting the hypothesis of co-incident linkage and consistent with incomplete pleiotropy at this locus. We conclude that polymorphisms at the QTL described in this study exert some genetic effects that are shared between Lp-PLA(2) activity and LDL-C concentration.
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