ArticleNutrition journal2007
The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers.
Article in Nutrition journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- The Anti-inflammatory Effect of Personalized Omega-3 Fatty Acid Dosing for Reducing Prostaglandin ECancer prevention research (Philadelphia, Pa.) · 2017Article
- A transcriptome-based protein network that identifies new therapeutic targets in colorectal cancer.BMC genomics · 2017Article
- Obesity-associated cancer risk: the role of intestinal microbiota in the etiology of the host proinflammatory state.Translational research : the journal of laboratory and clinical medicine · 2017Review
- Bardoxolone Methyl Prevents High-Fat Diet-Induced Colon Inflammation in Mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
- Peritumoral adipose tissue as a source of inflammatory and angiogenic factors in colorectal cancer.International journal of colorectal disease · 2016Article
- The critical roles of miR-21 in anti-cancer effects of curcumin.Annals of translational medicine · 2015Review
- Esophageal COX-2 expression is increased in Barrett's esophagus, obesity, and smoking.Digestive diseases and sciences · 2015Article
- PPARδ and PGEInflammation and cell signaling · 2014Article
- Potentiation of colon cancer susceptibility in mice by colonic epithelial PPAR-δ/β overexpression.Journal of the National Cancer Institute · 2014Article
- Over-expression of COX-2 mRNA in colorectal cancer.BMC gastroenterology · 2014Article
- Potential targets for colorectal cancer prevention.International journal of molecular sciences · 2013Review
- Targeting peroxisome proliferator-activated receptor-β/δ in colon cancer: how to aim?Biochemical pharmacology · 2013Review
- The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention.Nature reviews. Cancer · 2012Review
- The Mediterranean diet: effects on proteins that mediate fatty acid metabolism in the colon.Nutrition reviews · 2011Review
- Aspirin use, body mass index, physical activity, plasma C-peptide, and colon cancer risk in US health professionals.American journal of epidemiology · 2011Article
- Primary prevention of colorectal cancer.Gastroenterology · 2010Review
- Article
- Sorting out the functional role(s) of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) in cell proliferation and cancer.Biochimica et biophysica acta · 2009Review
- Role of peroxisome-proliferator-activated receptor beta/delta (PPARbeta/delta) in gastrointestinal tract function and disease.Clinical science (London, England : 1979) · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidemiological studies on risk factors for colorectal cancer (CRC) have mainly focused on diet, and being overweight is now recognized to contribute significantly to CRC risk. Overweight and obesity are defined as an excess of adipose tissue mass and are associated with disorders in lipid metabolism. Peroxisome proliferator-activated receptors (PPARs) and retinoid-activated receptors (RARs and RXRs) are important modulators of lipid metabolism and cellular homeostasis. Alterations in expression and activity of these ligand-activated transcription factors might be involved in obesity-associated diseases, which include CRC. Cyclooxygenase-2 (COX-2) also plays a critical role in lipid metabolism and alterations in COX-2 expression have already been associated with unfavourable clinical outcomes in epithelial tumors. The objective of this study is to examine the hypothesis questioning the relationship between alterations in the expression of nuclear receptors and COX-2 and the weight status among male subjects with CRC.
methodThe mRNA expression of the different nuclear receptor subtypes and of COX-2 was measured in 20 resected samples of CRC and paired non-tumor tissues. The association between expression patterns and weight status defined as a body mass index (BMI) was statistically analyzed.
resultsNo changes were observed in PPAR gamma mRNA expression while the expression of PPAR delta, retinoid-activated receptors and COX-2 were significantly increased in cancer tissues compared to normal colon mucosa (P <or= 0.001). The weight status appeared to be an independent factor, although we detected an increased level of COX-2 expression in the normal mucosa from overweight patients (BMI >or= 25) compared to subjects with healthy BMI (P = 0.002).
conclusionOur findings show that alterations in the pattern of nuclear receptor expression observed in CRC do not appear to be correlated with patient weight status. However, the analysis of COX-2 expression in normal colon mucosa from subjects with a high BMI suggests that COX-2 deregulation might be driven by excess weight during the colon carcinogenesis process.
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