ArticleBritish journal of pharmacology2007
Oxygen-derived free radicals mediate endothelium-dependent contractions in femoral arteries of rats with streptozotocin-induced diabetes.
Article in British journal of pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Review
- Regional heterogeneity in vascular contractile dysfunction in diabetic mice.Molecular and cellular biochemistry · 2025Article
- Acute Metabolic Stress Induces Lymphatic Dysfunction Through KATP Channel Activation.Function (Oxford, England) · 2024Article
- Exercise training and vascular heterogeneity in db/db mice: evidence for regional- and duration-dependent effects.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- 17β-Estradiol Treatment Improves Acetylcholine-Induced Relaxation of Mesenteric Arteries in Ovariectomized UC Davis Type 2 Diabetes Mellitus Rats in Prediabetic State.Frontiers in physiology · 2022Article
- Potentiation of Acetylcholine-Induced Relaxation of Aorta in Male UC Davis Type 2 Diabetes Mellitus (UCD-T2DM) Rats: Sex-Specific Responses.Frontiers in physiology · 2021Article
- Article
- Activation of NQO-1 mediates the augmented contractions of isolated arteries due to biased activity of soluble guanylyl cyclase in their smooth muscle.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- Deletion of T-type calcium channels CaPflugers Archiv : European journal of physiology · 2018Article
- Genetic Deletion of ACE2 Induces Vascular Dysfunction in C57BL/6 Mice: Role of Nitric Oxide Imbalance and Oxidative Stress.PloS one · 2016Article
- Flavonols in the Prevention of Diabetes-induced Vascular Dysfunction.Journal of cardiovascular pharmacology · 2015Review
- Hydrogen peroxide elicits constriction of skeletal muscle arterioles by activating the arachidonic acid pathway.PloS one · 2014Article
- Sex differences in mesenteric endothelial function of streptozotocin-induced diabetic rats: a shift in the relative importance of EDRFs.American journal of physiology. Heart and circulatory physiology · 2012Article
- Adventitia-derived hydrogen peroxide impairs relaxation of the rat carotid artery via smooth muscle cell p38 mitogen-activated protein kinase.Antioxidants & redox signaling · 2011Article
- Balloon catheter injury abolishes phenylephrine-induced relaxation in the rat contralateral carotid.British journal of pharmacology · 2011Article
- COX-mediated endothelium-dependent contractions: from the past to recent discoveries.Acta pharmacologica Sinica · 2010Review
- Effect of glitazones on the progression of coronary artery disease in type 2 diabetes patients.Vascular health and risk management · 2010Review
- Oxidation by trace Cu2+ ions underlies the ability of ascorbate to induce vascular dysfunction in the rat perfused mesentery.European journal of pharmacology · 2009Article
- Endothelium-dependent contractions: when a good guy turns bad!The Journal of physiology · 2008Review
- Oxidative stress and COX cause hyper-responsiveness in vascular smooth muscle of the femoral artery from diabetic rats.British journal of pharmacology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe present experiments were designed to study the contribution of oxygen-derived free radicals to endothelium-dependent contractions in femoral arteries of rats with streptozotocin-induced diabetes. EXPERIMENTAL APPROACH: Rings with and without endothelium were suspended in organ chambers for isometric tension recording. The production of oxygen-derived free radicals in the endothelium was measured with 2',7'-dichlorodihydrofluorescein diacetate using confocal microscopy. The presence of protein was measured by western blotting. KEY
resultsIn the presence of L-NAME, the calcium ionophore A23187 induced larger endothelium-dependent contractions in femoral arteries from diabetic rats. Tiron, catalase, deferoxamine and MnTMPyP, but not superoxide dismutase reduced the response, suggesting that oxygen-derived free radicals are involved in the endothelium-dependent contraction. In the presence of L-NAME, A23187 increased the fluorescence signal in femoral arteries from streptozotocin-treated, but not in those from control rats, confirming that the production of oxygen-derived free radicals contributes to the enhanced endothelium-dependent contractions in diabetes. Exogenous H2O2 caused contractions in femoral arterial rings without endothelium which were reduced by deferoxamine, indicating that hydroxyl radicals contract vascular smooth muscle and thus could be an endothelium-derived contracting factor in diabetes. The reduced presence of Mn-SOD and the decreased activity of catalase in femoral arteries from streptozotocin-treated rats demonstrated the presence of a redox abnormality in arteries from rats with diabetes. CONCLUSIONS AND IMPLICATIONS: These findings suggest that the redox abnormality resulting from diabetes increases oxidative stress which facilitates and/or causes endothelium-dependent contractions.
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