ArticleAnatomy and embryology1991
Glial cell differentiation in neuron-free and neuron-rich regions. II. Early appearance of S-100 protein positive astrocytes in human fetal hippocampus.
Article in Anatomy and embryology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Spatial-temporal representation of the astroglial markers in the developing human cortex.Brain structure & function · 2024Article
- S100B actions on glial and neuronal cells in the developing brain: an overview.Frontiers in neuroscience · 2024Review
- Article
- Astrocyte-Neuron Signaling in Synaptogenesis.Frontiers in cell and developmental biology · 2021Review
- The Proliferation of Dentate Gyrus Progenitors in the Ferret Hippocampus by Neonatal Exposure to Valproic Acid.Frontiers in neuroscience · 2021Article
- Astrogliogenesis in human fetal brain: complex spatiotemporal immunoreactivity patterns of GFAP, S100, AQP4 and YKL-40.Journal of anatomy · 2019Review
- Expression of the homeobox genes OTX2 and OTX1 in the early developing human brain.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
- Distribution patterns of vimentin-immunoreactive structures in the human prosencephalon during the second half of gestation.Journal of anatomy · 1999Article
- Early effects of iodine deficiency on radial glial cells of the hippocampus of the rat fetus. A model of neurological cretinism.The Journal of clinical investigation · 1997Article
- Abnormal exploratory behavior in transgenic mice carrying multiple copies of the human gene for S100 beta.Journal of psychiatry & neuroscience : JPN · 1995Article
- Glial cell differentiation in neuron-free and neuron-rich regions. I. Selective appearance of S-100 protein in radial glial cells of the hippocampal fimbria in human fetuses.Anatomy and embryology · 1991Article
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3 authors at 1 institution in 1 country.
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Abstract
The development of the human fetal hippocampus and dentate gyrus has been studied immunocytochemically. The first glial cells to appear are vimentin-positive radial glial cells. A gradual transition from vimentin to glial fibrillary acidic protein (GFAP) reactivity in the radial glial cells occurs at week 8. The GFAP-positive radial glial cells transform into astrocytes from week 14. A population of small S-100-positive somata which morphologically and spatially are distinct from GFAP-positive radial glial cells and their transformed progeny, are found as early as week 9.5 in the hippocampus during the period of peak neurogenesis. The well-defined immunoreactivity of the morphologically homogenous cell subpopulation for S-100 protein, which has been used as an astrocytic marker in the adult hippocampus, indicates that astrocytes may differentiate at very early gestational ages in human fetuses. The S-100-positive astrocytes are thought to be derived from ventricular zone cells, which at the time of their appearance do not express any of the applied astrocytic markers (S-100, GFAP, vimentin). It is suggested that the S-100-positive astrocytic cell population interacts with the first incoming projection fibers, so modulating the pattern of connectivity.
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