ArticlePsychosomatic medicine
Sleep quality varies as a function of 5-HTTLPR genotype and stress.
Article in Psychosomatic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- Correlates of Sleep Disturbance Experienced by Informal Caregivers of Persons Living with Dementia: A Systematic Review.Clinical gerontologistPooled it
- The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the sleep-promoting effects of tryptophan: A randomized placebo-controlled crossover study.Journal of psychopharmacology (Oxford, England) · 2019Trial
- Interaction between 5-HTTLPR genotype and cognitive stress vulnerability on sleep quality: effects of sub-chronic tryptophan administration.The international journal of neuropsychopharmacology · 2015Trial
- The effect of vestibular stimulation in a four-hour sleep phase advance model of transient insomnia.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2010Trial
- Sleep quality is associated with default mode and salience network connectivity differently across age and sex.Neurobiology of aging · 2026Article
- Article
- A Cross-Sectional Study on the Relationship Among Cytokines, 5-HT2A Receptor Polymorphisms, and Sleep Quality of Non-manual Workers in Xinjiang, China.Frontiers in psychiatry · 2022Article
- The Genetics of Sleep Disorders in Children: A Narrative Review.Brain sciences · 2021Review
- It's Not the Genes OR the Environment, It's the Genes AND the Environment!Journal of the American Heart Association · 2021Article
- Polymorphism of the Serotonin Transporter Gene and the Peripheral 5-Hydroxytryptamine in Obstructive Sleep Apnea: What Do We Know and What are We Looking for? A Systematic Review of the Literature.Nature and science of sleep · 2021Review
- Maternal neglect and the serotonin system are associated with daytime sleep in infant rhesus monkeys.Development and psychopathology · 2020Article
- When Distress Becomes Somatic: Dementia Family Caregivers' Distress and Genetic Vulnerability to Pain and Sleep Problems.The Gerontologist · 2019Article
- The impact of stress on sleep: Pathogenic sleep reactivity as a vulnerability to insomnia and circadian disorders.Journal of sleep research · 2018Review
- Relationship between Job Stress and 5-HT2A Receptor Polymorphisms on Self-Reported Sleep Quality in Physicians in Urumqi (Xinjiang, China): A Cross-Sectional Study.International journal of environmental research and public health · 2018Article
- Sleep-Related Attentional Bias in Insomnia: Time to Examine Moderating Factors?Frontiers in psychology · 2018Article
- Article
- Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence.American heart journal · 2017Article
- Genetic Pathways to Insomnia.Brain sciences · 2016Review
- Article
- Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo test the hypothesis that allelic variation in 5HTT gene-linked polymorphic region (5-HTTLPR) genotype was associated with sleep quality (Pittsburgh Sleep Quality Index, PSQI) as a main effect and as moderated by the chronic stress of caregiving. Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro.
methodsSubjects were 142 adult primary caregivers for a spouse or parent with dementia and 146 noncaregiver controls. Subjects underwent genotyping and completed the PSQI.
resultsVariation in 5-HTTLPR genotype was not related to sleep quality as a main effect (p > .36). However, there was a caregiver X 5-HTTLPR interaction (p < .009), such that the s allele was associated with poorer sleep quality in caregivers as compared with controls.
conclusionsFindings suggest that the s allele may moderate sleep disturbance in response to chronic stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.