ArticleProtein science : a publication of the Protein Society2007
The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction.
Article in Protein science : a publication of the Protein Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
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- Cryo-EM structures of the full-length human contactin-2.The FEBS journal · 2025Article
- Molecular mechanism of contactin 2 homophilic interaction.Structure (London, England : 1993) · 2024Article
- Structural insights into the contactin 1 - neurofascin 155 adhesion complex.Nature communications · 2022Article
- A conserved Neurite Outgrowth and Guidance motif with biomimetic potential in neuronal Cell Adhesion Molecules.Computational and structural biotechnology journal · 2021Article
- Fetal Central Nervous System Derived Extracellular Vesicles: Potential for Non-invasive Tracking of Viral Mediated Fetal Brain Injury.Frontiers in virology (Lausanne, Switzerland) · 2021Article
- Novel biomarkers to assess in utero effects of maternal opioid use: First steps toward understanding short- and long-term neurodevelopmental sequelae.Genes, brain, and behavior · 2019Article
- Latrophilin's Social Protein Network.Frontiers in neuroscience · 2019Review
- Architecture of cell-cell adhesion mediated by sidekicks.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Diagnostic Potential of Neural Exosome Cargo as Biomarkers for Acute Brain Injury.Annals of clinical and translational neurology · 2018Article
- Contactin-2/TAG-1, active on the front line for three decades.Cell adhesion & migration · 2017Article
- Article
- Manduca Contactin Regulates Amyloid Precursor Protein-Dependent Neuronal Migration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Novel window on early human neurodevelopment via fetal exosomes in maternal blood.Annals of clinical and translational neurology · 2016Article
- Herpes B virus gD interaction with its human receptor--an in silico analysis approach.Theoretical biology & medical modelling · 2014Article
- Specific contactin N-glycans are implicated in neurofascin binding and autoimmune targeting in peripheral neuropathies.The Journal of biological chemistry · 2014Article
- Regulation of adhesion by flexible ectodomains of IgCAMs.Neurochemical research · 2013Review
- Contactin 4, -5 and -6 differentially regulate neuritogenesis while they display identical PTPRG binding sites.Biology open · 2013Article
- Homophilic interaction of the L1 family of cell adhesion molecules.Experimental & molecular medicine · 2012Review
- A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human TAG-1 is a neural cell adhesion molecule that is crucial for the development of the nervous system during embryogenesis. It consists of six immunoglobulin-like and four fibronectin III-like domains and is anchored to the membrane by glycosylphosphatidylinositol. Herein we present the crystal structure of the four N-terminal immunoglobulin-like domains of TAG-1 (TAG-1(Ig1-4)), known to be important in heterophilic and homophilic macromolecular interactions. The contacts of neighboring molecules within the crystal were investigated. A comparison with the structure of the chicken ortholog resulted in an alternative mode for the molecular mechanism of homophilic TAG-1 interaction. This mode of TAG-1 homophilic interaction is based on dimer formation rather than formation of a molecular zipper as proposed for the chicken ortholog.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.