ArticleBiophysical journal2007
Influence of monolayer-monolayer coupling on the phase behavior of a fluid lipid bilayer.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 84 citations in OpenAlex.
- Quantifying interleaflet coupling of phase behavior and observing anti-registered phases in asymmetric lipid bilayers.Biophysical journal · 2026Article
- Quantifying interleaflet coupling of phase behavior and observing anti-registered phases in asymmetric lipid bilayers.bioRxiv : the preprint server for biology · 2026Article
- The Importance of Bilayer Asymmetry in Biological Membranes: Insights from Model Membranes.Membranes · 2025Review
- Disruption of liquid/liquid phase separation in asymmetric GUVs prepared by hemifusion.bioRxiv : the preprint server for biology · 2024Article
- Seeing the Membrane from Both Sides Now: Lipid Asymmetry and Its Strange Consequences.Cold Spring Harbor perspectives in biology · 2023Review
- Experimentally determined leaflet-leaflet phase diagram of an asymmetric lipid bilayer.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Building Asymmetric Lipid Bilayers for Molecular Dynamics Simulations: What Methods Exist and How to Choose One?Membranes · 2023Review
- Physical Concept to Explain the Regulation of Lipid Membrane Phase Separation under Isothermal Conditions.Life (Basel, Switzerland) · 2023Review
- Sensing a little friction.Biophysical journal · 2022Article
- Article
- Investigation of the domain line tension in asymmetric vesicles prepared via hemifusion.Biochimica et biophysica acta. Biomembranes · 2021Article
- Role of Transmembrane Proteins for Phase Separation and Domain Registration in Asymmetric Lipid Bilayers.Biomolecules · 2019Article
- Effects of Passive Phospholipid Flip-Flop and Asymmetric External Fields on Bilayer Phase Equilibria.Biophysical journal · 2018Article
- Roles of Interleaflet Coupling and Hydrophobic Mismatch in Lipid Membrane Phase-Separation Kinetics.Journal of the American Chemical Society · 2016Article
- Relaxation dynamics of two-component fluid bilayer membranes.The European physical journal. E, Soft matter · 2016Article
- Interleaflet Coupling, Pinning, and Leaflet Asymmetry-Major Players in Plasma Membrane Nanodomain Formation.Frontiers in cell and developmental biology · 2016Review
- Transbilayer Colocalization of Lipid Domains Explained via Measurement of Strong Coupling Parameters.Biophysical journal · 2015Article
- Registered and antiregistered phase separation of mixed amphiphilic bilayers.Biophysical journal · 2015Article
- Macroscopic phase separation, modulated phases, and microemulsions: a unified picture of rafts.Biophysical journal · 2014Article
- Interleaflet coupling and domain registry in phase-separated lipid bilayers.Biophysical journal · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We suggest a minimal model for the coupling of the lateral phase behavior in an asymmetric lipid membrane across its two monolayers. Our model employs one single order parameter for each monolayer leaflet, namely its composition. Regular solution theory on the mean-field level is used to describe the free energy in each individual leaflet. Coupling between monolayers entails an energy penalty for any local compositional differences across the membrane. We calculate and analyze the phase behavior of this model. It predicts a range of possible scenarios. A monolayer with a propensity for phase separation is able to induce phase separation in the apposed monolayer. Conversely, a monolayer without this propensity is able to prevent phase separation in the apposed monolayer. If there is phase separation in the membrane, it may lead to either complete or partial registration of the monolayer domains across the membrane. The latter case which corresponds to a three-phase coexistence is only found below a critical coupling strength. We calculate that critical coupling strength. Above the critical coupling strength, the membrane adopts a uniform compositional difference between its two monolayers everywhere in the membrane, implying phase coexistence between only two phases and thus perfect spatial registration of all domains on the apposed membrane leafs. We use the lattice Boltzmann simulation method to also study the morphologies that form during phase separation within the three-phase coexistence region. Generally, domains in one monolayer diffuse but remain fully enclosed within domains in the other monolayer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.