ArticleBiophysical journal2008
Mechanism of auxin interaction with Auxin Binding Protein (ABP1): a molecular dynamics simulation study.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 53 citations in OpenAlex.
- Evaluation of allelopathic potentialities of an invasive taxon, Mesosphaerum suaveolens (L.) Kuntze, and bio-assay-guided identification of the involved allelochemicals.Scientific reports · 2026Article
- Using Short Molecular Dynamics Simulations to Determine the Important Features of Interactions in Antibody-Protein Complexes.Proteins · 2025Article
- New Insights into the Enhancement of Adventitious Root Formation Using N,N'-Bis(2,3-methylenedioxyphenyl)urea.Plants (Basel, Switzerland) · 2023Article
- Application of data fusion modeling for the prediction of auxin response elements in Zea mays for food security purposes.Genomics & informatics · 2022Article
- Identification of differentially expressed genes in salt-tolerant oilseed sunflower (Helianthus annuus L.) genotype by RNA sequencing.Molecular biology reports · 2022Article
- The Story of Auxin-Binding Protein 1 (ABP1).Cold Spring Harbor perspectives in biology · 2021Review
- Genome-wide identification and interactome analysis of members of two-component system in Banana.BMC genomics · 2019Article
- The first dipeptidyl peptidase III from a thermophile: Structural basis for thermal stability and reduced activity.PloS one · 2018Article
- Revisiting Apoplastic Auxin Signaling Mediated by AUXIN BINDING PROTEIN 1.Molecules and cells · 2015Review
- Auxin binding-protein1 (ABP1), a receptor to regulate auxin transport and early auxin genes in an interlocking system with PIN proteins and the receptor TIR1.Plant signaling & behavior · 2011Article
- Article
- ABP1: an auxin receptor for fast responses at the plasma membrane.Plant signaling & behavior · 2010Article
- The auxin-binding pocket of auxin-binding protein 1 comprises the highly conserved boxes a and c.Planta · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Auxin Binding Protein 1 (ABP1) is ubiquitous in green plants. It binds the phytohormone auxin with high specificity and affinity, but its role in auxin-induced processes is unknown. To understand the proposed receptor function of ABP1 we carried out a detailed molecular modeling study. Molecular dynamics simulations showed that ABP1 can adopt two conformations differing primarily in the position of the C-terminus and that one of them is stabilized by auxin binding. This is in agreement with experimental evidence that auxin induces changes at the ABP1 C-terminus. Simulations of ligand egress from ABP1 revealed three main routes by which an auxin molecule can enter or leave the ABP1 binding site. Assuming the previously proposed orientation of ABP1 to plant cell membranes, one of the routes leads to the membrane and the other two to ABP1's aqueous surroundings. A network of hydrogen-bonded water molecules leading from the bulk water to the zinc-coordinated ligands in the ABP1 binding site was formed in all simulations. Water entrance into the zinc coordination sphere occurred simultaneously with auxin egress. These results suggest that the hydrogen-bonded water molecules may assist in protonation and deprotonation of auxin molecules and their egress from the ABP1 binding site.
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