ReviewAdvances in virus research2007
Use of functional genomics to understand influenza-host interactions.
Review in Advances in virus research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease.PLoS pathogens · 2021Article
- Differential proteomic analysis of respiratory samples from patients suffering from influenza.Virusdisease · 2016Article
- Animal models for influenza virus pathogenesis, transmission, and immunology.Journal of immunological methods · 2014Review
- Systems approaches to influenza-virus host interactions and the pathogenesis of highly virulent and pandemic viruses.Seminars in immunology · 2013Review
- Proteome alterations in primary human alveolar macrophages in response to influenza A virus infection.Journal of proteome research · 2012Article
- The type I interferon response during viral infections: a "SWOT" analysis.Reviews in medical virology · 2012Review
- Macaque proteome response to highly pathogenic avian influenza and 1918 reassortant influenza virus infections.Journal of virology · 2010Article
- Transcriptomics and proteomics in the study of H1N1 2009.Genomics, proteomics & bioinformatics · 2010Review
- Evolutionary dynamics of human rotaviruses: balancing reassortment with preferred genome constellations.PLoS pathogens · 2009Article
- Applications of high-throughput genomics to antiviral research: evasion of antiviral responses and activation of inflammation during fulminant RNA virus infection.Antiviral research · 2009Review
- Innate immune modulation by RNA viruses: emerging insights from functional genomics.Nature reviews. Immunology · 2008Review
- SARS-CoV virus-host interactions and comparative etiologies of acute respiratory distress syndrome as determined by transcriptional and cytokine profiling of formalin-fixed paraffin-embedded tissues.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Infection with influenza typically results in mild-to-moderate illness in healthy individuals; however, it is responsible for 30,000-40,000 deaths each year in the United States. In extreme cases, such as the influenza pandemic of 1918, tens of millions of people have died from the infection. To prepare for future influenza outbreaks, it is necessary to understand how the virus interacts with the host and to determine what makes certain strains of influenza highly pathogenic. Functional genomics provides a unique approach to this effort by allowing researchers to examine the effect of influenza infection on global host mRNA levels. Researchers are making increasing use of this approach to study virus-host interactions using a variety of model systems. For example, data obtained using microarray technology, in combination with mouse and macaque infection models, is providing exciting new insights into the pathogenicity of the 1918 virus. These studies suggest that the lethality associated with this virus is in part due to an aberrant and unchecked immune response. Progress is also being made toward using functional genomics in the diagnosis and prognosis of acute lung infections and in the development of more effective influenza vaccines and antivirals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.