ArticleJournal of the American College of Cardiology2007
Frequency and distribution of thin-cap fibroatheroma and ruptured plaques in human coronary arteries: a pathologic study.
Article in Journal of the American College of Cardiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
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Who cites it
103 citing papers in PubMed, 350 citations in OpenAlex.
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- Everolimus-eluting bioresorbable stent vs. durable polymer everolimus-eluting metallic stent in patients with ST-segment elevation myocardial infarction: results of the randomized ABSORB ST-segment elevation myocardial infarction-TROFI II trial.European heart journal · 2016Trial
- Comparison of the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by tissue characterization using serial virtual histology intravascular ultrasound.Heart and vessels · 2015Trial
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- Relationship between cardiovascular risk factors and biomarkers with necrotic core and atheroma size: a serial intravascular ultrasound radiofrequency data analysis.The international journal of cardiovascular imaging · 2012Trial
- Hidden risk in normal myocardial perfusion scans: AI-detected proximal coronary calcium on CT attenuation maps improves prognosis.European journal of nuclear medicine and molecular imaging · 2026Article
- Is Imaging of a Single Vessel Sufficient to Assess Pan-Coronary Vulnerability?Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- Coronary plaque healing: a safety net or a hazard indicator?Journal of thrombosis and thrombolysis · 2026Review
- Computational Analysis of Intravascular OCT Images for Future Clinical Support: A Comprehensive Review.IEEE reviews in biomedical engineering · 2026Review
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- Following the Dynamic Changes of Coronary Atherosclerosis: An Uphill Battle.Journal of the American Heart Association · 2024Article
- Electrochemical impedance spectroscopy unmasks high-risk atherosclerotic features in human coronary artery disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Coronary artery calcification burden, atherogenic index of plasma, and risk of adverse cardiovascular events in the general population: evidence from a mediation analysis.Lipids in health and disease · 2024Article
- Plaque Characteristics Derived from Intravascular Optical Coherence Tomography That Predict Cardiovascular Death.Bioengineering (Basel, Switzerland) · 2024Article
- Increased incidence of napkin-ring sign plaques on cervicocerebral computed tomography angiography associated with the risk of acute ischemic stroke occurrence.European radiology · 2024Article
- X-box Binding Protein 1: An Adaptor in the Pathogenesis of Atherosclerosis.Aging and disease · 2023Review
- Coronary Artery Calcium Scoring in Asymptomatic Patients.HCA healthcare journal of medicine · 2023Review
- Plaque histology and myocardial disease in sudden coronary death: the Fingesture study.European heart journal · 2022Article
- Pharmaco-invasive therapy: Early implementation of statins and proprotein convertase subtilisin/kexin type 9 inhibitors after acute coronary syndrome.Frontiers in cardiovascular medicine · 2022Review
- Optical Coherence Tomography of Plaque Vulnerability and Rupture: JACC Focus Seminar Part 1/3.Journal of the American College of Cardiology · 2021Review
43 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesOur purpose was to quantify the frequency and distribution of suspected vulnerable lesions, defined as thin-capped fibroatheroma (TCFA) and ruptured plaque, in human coronary artery autopsy specimens.
backgroundMost acute coronary events and sudden death are believed to arise from rupture of a TCFA followed by thrombosis. Although there is general agreement that clinical events are usually caused by focal lesions, there is considerable debate over the relative importance of focal versus systemic factors in the pathogenesis of atherosclerosis.
methodsWe longitudinally sectioned coronary arteries from 50 whole hearts taken from patients (mean age 73 years, 64% men) dying of cardiovascular (n = 33), noncardiovascular (n = 13), and unknown (n = 4) causes. A total of 3,639 longitudinal segments of length 3 mm were sectioned from 148 arteries, accounting for 10.9 m of total tissue length. Specimens were classified on the basis of histology and computer-aided morphometry.
resultsTwenty-three TCFA and 19 ruptured plaques were found (mean +/- SD: 0.46 +/- 0.95 and 0.38 +/- 0.70 per heart, respectively), and these lesions accounted for only 1.6% and 1.2%, respectively, of the total length of the coronary tree examined in patients dying of cardiovascular causes. The majority of TCFA and ruptured plaque localized in the proximal third of the major coronary arteries, and in 92% of cases these lesions clustered within 2 or fewer nonoverlapping 20-mm segments.
conclusionsThe suspected precursors of rupture-mediated thrombosis occur in a limited, focal distribution in the coronary arteries.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.