ArticleEuropean journal of cancer (Oxford, England : 1990)2007
Green tea catechin (-)-epicatechin gallate induces tumour suppressor protein ATF3 via EGR-1 activation.
Article in European journal of cancer (Oxford, England : 1990), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- AMPK-Targeting Effects of (-)-Epicatechin Gallate fromInternational journal of molecular sciences · 2025Article
- Natural Products in the Prevention of Metabolic Diseases: Lessons Learned from the 20th KAST Frontier Scientists Workshop.Nutrients · 2021Review
- Kahweol from Coffee Induces Apoptosis by Upregulating Activating Transcription Factor 3 in Human Colorectal Cancer Cells.Biomolecules & therapeutics · 2017Article
- A novel ECG analog 4-(S)-(2,4,6-trimethylthiobenzyl)-epigallocatechin gallate selectively induces apoptosis of B16-F10 melanoma via activation of autophagy and ROS.Scientific reports · 2017Article
- In Vitro Anticancer Activity of Phlorofucofuroeckol A via Upregulation of Activating Transcription Factor 3 against Human Colorectal Cancer Cells.Marine drugs · 2016Article
- EGR-1/Bax pathway plays a role in vitamin E δ-tocotrienol-induced apoptosis in pancreatic cancer cells.The Journal of nutritional biochemistry · 2015Article
- The induction of activating transcription factor 3 (ATF3) contributes to anti-cancer activity of Abeliophyllum distichum Nakai in human colorectal cancer cells.BMC complementary and alternative medicine · 2014Article
- Anti-cancer activity of Ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells.BMC complementary and alternative medicine · 2014Article
- Repression of phosphoinositide-dependent protein kinase 1 expression by ciglitazone via Egr-1 represents a new approach for inhibition of lung cancer cell growth.Molecular cancer · 2014Article
- 3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells.The Journal of nutritional biochemistry · 2013Article
- Patulin induces colorectal cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation.Cellular signalling · 2012Article
- COX inhibitors directly alter gene expression: role in cancer prevention?Cancer metastasis reviews · 2011Review
- Resveratrol-induced apoptosis is mediated by early growth response-1, Krüppel-like factor 4, and activating transcription factor 3.Cancer prevention research (Philadelphia, Pa.) · 2011Article
- Gene expression analysis of cell death induction by taurolidine in different malignant cell lines.BMC cancer · 2010Article
- Activating transcription factor 2 (ATF2) controls tolfenamic acid-induced ATF3 expression via MAP kinase pathways.Oncogene · 2010Article
- A potential proliferative gene, NUDT6, is down-regulated by green tea catechins at the posttranscriptional level.The Journal of nutritional biochemistry · 2010Article
- In vitro anti-proliferative activity of alcoholic stem extract of Coscinium fenestratum in human colorectal cancer cells.Experimental and therapeutic medicine · 2010Article
- ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells.Molecular cancer therapeutics · 2008Article
- A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer.Gastroenterology · 2008Article
- A non-targeted approach to chemical discrimination between green tea dietary supplements and green tea leaves by HPLC/MS.Journal of AOAC InternationalArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Epicatechin gallate (ECG) is the third major catechin component in green tea, but it shows strong biological activity in some aspects, including apoptosis, cell growth inhibition, and membrane transport system in various cells. We previously reported that ECG induces activating transcription factor 3 (ATF3), which is involved in pro-apoptosis in HCT-116 cells. In this report, we present a molecular mechanism by which ECG induces ATF3 expression at the transcriptional level. We found that Sp3 contributed to the basal expression of the ATF3 gene, whereas EGR-1 played an important role in ECG-induced ATF3 expression in HCT-116 cells, as assessed by EMSA and co-transfection experiments. These results suggested that EGR-1, a tumour suppressor protein, could substantiate ECG's role of ATF3 expression in human colorectal cancer cells. We also found that pro-oxidant activity of ECG contributed to ECG-induced ATF3 expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.