ReviewBiochemical pharmacology2008
"Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice.
Review in Biochemical pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01320748 (fMRI Study of a Dual Process Treatment Protocol With Substance Dependent Adults), which is not on this map. Cited by 63 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
fMRI Study of a Dual Process Treatment Protocol With Substance Dependent Adults
Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 138 citations in OpenAlex.
- Genetics of methamphetamine use disorder: A systematic review and meta-analyses of gene association studies.Neuroscience and biobehavioral reviews · 2021Pooled it
- Genetic and environmental influences on cannabis use initiation and problematic use: a meta-analysis of twin studies.Addiction (Abingdon, England) · 2010Pooled it
- Structure and function of the human apoptotic scramblase Xkr4.Nature communications · 2025Article
- Voluntary nicotine consumption and reward in a subset of diversity outbred founder strains.Journal of psychopharmacology (Oxford, England) · 2024Article
- Exploring the Genomic Patterns in Human and Mouse Cerebellums Via Single-Cell Sequencing and Machine Learning Method.Frontiers in genetics · 2022Article
- The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers.Brain sciences · 2021Article
- Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Prenatal opioid exposure and vulnerability to future substance use disorders in offspring.Experimental neurology · 2021Review
- Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence.Molecular psychiatry · 2021Article
- Risk Assessment for Heroin Use and Craving Score Using Polygenic Risk Score.Journal of personalized medicine · 2021Article
- Common genetic substrates of alcohol and substance use disorder severity revealed by pleiotropy detection against GWAS catalog in two populations.Addiction biology · 2021Article
- LAR Receptor Tyrosine Phosphatase Family in Healthy and Diseased Brain.Frontiers in cell and developmental biology · 2021Review
- Attention-deficit/hyperactivity disorder and lifetime cannabis use: genetic overlap and causality.Molecular psychiatry · 2020Article
- Construction and Analysis of Protein-Protein Interaction Network of Heroin Use Disorder.Scientific reports · 2019Article
- Alcohol and Cocaine Exposure Modulates ABCB1 and ABCG2 Transporters in Male Alcohol-Preferring Rats.Molecular neurobiology · 2019Article
- Article
- The GABABrain sciences · 2018Article
- Neuroepigenetics and addiction.Handbook of clinical neurology · 2018Review
- The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction.Neural plasticity · 2018Review
- Cdh13 and AdipoQ gene knockout alter instrumental and Pavlovian drug conditioning.Genes, brain, and behavior · 2017Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Family, adoption and twin data each support substantial heritability for addictions. Most of this heritable influence is not substance-specific. The overlapping genetic vulnerability for developing dependence on a variety of addictive substances suggests large roles for "higher order" pharamacogenomics in addiction molecular genetics. We and others have now completed genome-wide association (GWA) studies of DNAs from individuals with dependence on a variety of addictive substances versus appropriate controls. Recently reported replicated GWA observations identify a number of genes based on comparisons between controls and European-American and African-American polysubstance abusers. Here we review the convergence between these results and data that compares control samples and (a) alcohol-dependent European-Americans, (b) methamphetamine-dependent Asians and (c) nicotine dependent samples from European backgrounds. We also compare these human data to quantitative trait locus (QTL) results from studies of addiction-related phenotypes in mice that focus on alcohol, methamphetamine and barbiturates. These comparisons support a genetic architecture built from largely polygenic contributions of common allelic variants to dependence on a variety of legal and illegal substances. Many of the gene variants identified in this way are likely to alter specification and maintenance of neuronal connections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.