ReviewJournal of structural and functional genomics2007
Structure-based inference of molecular functions of proteins of unknown function from Berkeley Structural Genomics Center.
Review in Journal of structural and functional genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed.
- Engagement of intrinsic disordered proteins in protein-protein interaction.Frontiers in molecular biosciences · 2023Article
- Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response.Progress in biophysics and molecular biology · 2021Article
- Learning the protein language: Evolution, structure, and function.Cell systems · 2021Article
- A Genetic System forFrontiers in microbiology · 2019Article
- An assessment of the amount of untapped fold level novelty in under-sampled areas of the tree of life.Scientific reports · 2015Article
- Structure and computational analysis of a novel protein with metallopeptidase-like and circularly permuted winged-helix-turn-helix domains reveals a possible role in modified polysaccharide biosynthesis.BMC bioinformatics · 2014Article
- The role of protein structural analysis in the next generation sequencing era.Topics in current chemistry · 2014Review
- Structure- and sequence-based function prediction for non-homologous proteins.Journal of structural and functional genomics · 2012Article
- Accelerating large-scale protein structure alignments with graphics processing units.BMC research notes · 2012Article
- Article
- From protein sequences to 3D-structures and beyond: the example of the UniProt knowledgebase.Cellular and molecular life sciences : CMLS · 2010Review
- Unravelling ancient microbial history with community proteogenomics and lipid geochemistry.Nature reviews. Microbiology · 2009Article
- Lessons from structural genomics.Annual review of biophysics · 2009Review
- Structural features and the persistence of acquired proteins.Proteomics · 2008Article
- De-orphaning the structural proteome through reciprocal comparison of evolutionarily important structural features.PloS one · 2008Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Advances in sequence genomics have resulted in an accumulation of a huge number of protein sequences derived from genome sequences. However, the functions of a large portion of them cannot be inferred based on the current methods of sequence homology detection to proteins of known functions. Three-dimensional structure can have an important impact in providing inference of molecular function (physical and chemical function) of a protein of unknown function. Structural genomics centers worldwide have been determining many 3-D structures of the proteins of unknown functions, and possible molecular functions of them have been inferred based on their structures. Combined with bioinformatics and enzymatic assay tools, the successful acceleration of the process of protein structure determination through high throughput pipelines enables the rapid functional annotation of a large fraction of hypothetical proteins. We present a brief summary of the process we used at the Berkeley Structural Genomics Center to infer molecular functions of proteins of unknown function.
Indexed as
Identifiers
17764033What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.