ArticleNeurochemical research2008
DARPP-32 and NCS-1 expression is not altered in brains of rats treated with typical or atypical antipsychotics.
Article in Neurochemical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
- Emerging Roles of Neuronal CaFrontiers in molecular neuroscience · 2019Review
- NCS-1 is a regulator of calcium signaling in health and disease.Biochimica et biophysica acta. Molecular cell research · 2018Review
- Multiple roles for frequenin/NCS-1 in synaptic function and development.Molecular neurobiology · 2012Review
- Detailed DARPP-32 expression profiles in postmortem brains from patients with schizophrenia: an immunohistochemical study.Medical molecular morphology · 2011Article
- Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- DARPP-32, Jack of All Trades… Master of Which?Frontiers in behavioral neuroscience · 2011Article
- Downregulation of the cAMP/PKA pathway in PC12 cells overexpressing NCS-1.Cellular and molecular neurobiology · 2011Article
- Beyond the dopamine receptor: regulation and roles of serine/threonine protein phosphatases.Frontiers in neuroanatomy · 2011Article
- Lack of effects of typical and atypical antipsychotics in DARPP-32 and NCS-1 levels in PC12 cells overexpressing NCS-1.Journal of negative results in biomedicine · 2010Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopamine-mediated neurotransmission imbalances are associated with several psychiatry illnesses, such as schizophrenia. Recently it was demonstrated that two proteins involved in dopamine signaling are altered in prefrontal cortex (PFC) of schizophrenic patients. DARPP-32 is a key downstream effector of intracellular signaling pathway and is downregulated in PFC of schizophrenic subjects. NCS-1 is a neuronal calcium sensor that can inhibit dopamine receptor D2 internalization and is upregulated in PFC of schizophrenic subjects. It is well known that dopamine D2 receptor is the main target of antipsychotic. Therefore, our purpose was to study if chronic treatment with typical or atypical antipsychotics induced alterations in DARPP-32 and NCS-1 expression in five brain regions: prefrontal cortex, hippocampus, striatum, cortex and cerebellum. We did not find any changes in DARPP-32 and NCS-1 protein expression in any brain region investigated.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.