Trial reportJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2007
Medical and surgical treatment of chronic anal fissure: a prospective study.
Trial report in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Botulinum toxin and anal fissure: efficacy and safety systematic review.International journal of colorectal disease · 2012Pooled it
- Idiopathic hypertensive anal canal: a place of internal sphincterotomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2009Trial
- Glyceryl trinitrate ointment (0.25%) and anal cryothermal dilators in the treatment of chronic anal fissures.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2009Trial
- Fissurectomy versus lateral internal sphincterotomy in the treatment of chronic anal fissures: no advantages in terms of post-operative incontinence.Techniques in coloproctology · 2023Article
- Influence of COVID-19 Pandemic on Colorectal Cancer Presentation, Management and Outcome during the COVID-19 Pandemic.Journal of clinical medicine · 2023Article
- Thoracic Duct Embolization for Delayed Chyle Leak After Lewis-Tanner Esophagectomy.The American journal of case reports · 2022Article
- Immunonutrition reduces complications rate and length of stay after laparoscopic total gastrectomy: a single unit retrospective study.Discover oncology · 2022Article
- Benign Anorectal Disorders and Pelvic Floor Disease After Bariatric Surgery.Journal of clinical medicine research · 2022Review
- Synchronous liver and peritoneal metastases from colorectal cancer: Is cytoreductive surgery and hyperthermic intraperitoneal chemotherapy combined with liver resection a feasible option?Frontiers in surgery · 2022Review
- Therapeutic properties of botulinum toxin on chronic anal fissure treatment and the patient factors role.Journal of family medicine and primary care · 2020Article
- Comparison of topical nifedipine with oral nifedipine for treatment of anal fissure: a randomized controlled trial.Iranian Red Crescent medical journal · 2014Article
- Long term outcomes after lateral anal sphincterotomy for anal fissure: a retrospective cohort study.Surgery today · 2014Article
- Morbidity associated with treatment of chronic anal fissure.Pakistan journal of medical sciences · 2013Article
- Effect of chronic anal fissure components on isosorbide dinitrate treatment.World journal of surgery · 2012Article
- Conservative and surgical treatment of chronic anal fissure: prospective longer term results.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2010Article
- Beyond Beauty : Botulinum Toxin Use in Anal Fissure.Medical journal, Armed Forces India · 2009Article
- A pilot comparative study of fissurectomy/diltiazem and fissurectomy/botulinum toxin in the treatment of chronic anal fissure.Techniques in coloproctology · 2008Article
- Continence disorders after anal surgery--a relevant problem?International journal of colorectal disease · 2008Review
- Pharmacological sphincterotomy for chronic anal fissures by botulinum toxin a.Journal of cutaneous and aesthetic surgery · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this prospective study was to assess the efficacy of different medical treatments and surgery in the treatment of chronic anal fissure (CAF). From 1/04 to 09/06, 156 patients with typical CAF completed the study. All patients were treated with 0.2% nitroglycerin ointment (GTN) or anal dilators (DIL) for 8 weeks. If no improvement was observed after 8 weeks, patient was assigned to the other treatment or a combination of the two. Persisting symptoms after 12 weeks or recurrence were indications for either botulinum toxin injection into the internal sphincter and fissurectomy or lateral internal sphincterotomy (LIS). During the follow-up (19 +/- 8 months), healing rates, symptoms, incontinence scores, and therapy adverse effects were prospectively recorded. Overall healing rates were 65.3 and 96.3% after GTN/DIL or BTX/LIS. Healing rate after GTN or DIL were 39.8 and 46%, respectively. Thirty-six patients (23.1%) responded to further medical therapy. Fifty-four patients (34.6%) underwent BTX or LIS. Healing rate after BTX was 81.8%. LIS group showed a 100% healing rate with no morbidity and postoperative incontinence. In conclusion, although LIS is far more effective than medical treatments, BTX injection/fissurectomy as first line treatment may significantly increase the healing rate while avoiding any risk of incontinence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.